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Permanent Pathology Job in Las Cruces New Mexico with Community Health Systems
Join a private practice in Las Cruces NM. Las Cruces is a beautiful and growing community, nestled in the mountains and mesas of southern New Mexico. Located just 45 minutes away is El Paso International
Permanent Pathology Job in Riverton Wyoming with Riverton Memorial Hospital
Physician Pathology Beautiful Wyoming Wind River Country Seeking a pathologist for 70 bed hospital. Surgical specialties: orthopedics, ent, ophthalmology, general surgery, bariatric surgery, urology,
Locum Tenens Pathology Job in Florham Park New Jersey with Medical Search International
Great $$$-BC/BE Pathologist-Locum Tenens-Northern New Jersey Seeking a BC/BE Pathologist for a Locum Tenens assignment in New Jersey. 90-180 days (may be extended). This position may be converted to
Annals of Clinical Microbiology and Antimicrobials - Latest articles
Pitfalls in efficacy testing – how important is the validation of neutralization of chlorhexidine digluconate?
Mirja Reichel, Peter Heisig and Günter Kampf Tue, 02 Dec 2008 00:00:00 -0000
Background: Effective neutralization of active agents is essential to obtain valid efficacy results, especially when non-volatile active agents like chlorhexidine digluconate (CHG) are tested. The aim of this study was to determine an effective and non-toxic neutralizing mixture for a propan-1-ol solution containing 2% CHG. Methods: Experiments were carried out according to ASTM E 1054-02. The neutralization capacity was tested separately with five challenge microorganisms in suspension, and with a rayon swab carrier. Either 0.5 mL of the antiseptic solution (suspension test) or a saturated swab with the antiseptic solution (carrier test) was added to tryptic soy broth containing neutralizing agents. After the samples were mixed, aliquots were spread immediately and after 3 h of storage at 2 – 8°C onto tryptic soy agar containing a neutralizing mixture. Results: The neutralizer was, however, not consistently effective in the suspension test. Immediate spread yielded a valid neutralization with Staphylococcus aureus, Staphylococcus epidermidis and Corynebacterium jeikeium but not with Micrococcus luteus (p < 0.001) and Candida albicans (p < 0.001). A 3-h storage period of the neutralized active agents in suspension resulted in significant carry-over activity of CHG in addition against Staphylococcus epidermidis (p < 0.001) and Corynebacterium jeikeium (p = 0.044). In the carrier test, the neutralizing mixture was found to be effective and non toxic to all challenge microorganisms when spread immediately. However, after 3 h storage of the neutralized active agents significant carry-over activity of CHG against Micrococcus luteus (p = 0.004; Tukey HSD) was observed. Conclusion: Without effective neutralization in the sampling fluid, non-volatile active ingredients will continue to reduce the number of surviving microorganisms after antiseptic treatment even if the sampling fluid is kept cold straight after testing. This can result in false-positive antiseptic efficacy data. Attention should be paid during the neutralization validation process to the amount of antiseptic solution, the storage time and to the choice of appropriate and sensitive microorganisms.
Brachyspira pilosicoli bloodstream infections: Case report and review of the literature
Lilia Bait-Merabet, Arnaud Thille, Patrick Legrand, Christian Brun-Buisson and Vincent Cattoir Thu, 25 Sep 2008 00:00:00 -0000
Brachyspira pilosicoli is the etiologic agent of human and animal intestinal spirochetosis and is rarely implicated as a cause of bacteremia. Here, we describe the case of a B. pilosicoli spirochetemia in a 53-year-old male patient suffering from cardiogenic shock. This fastidious bacterium was isolated from blood, likely after translocation from the intestinal tract. Blood cultures were positive after 5 days of incubation (one day after the patient's death), highlighting the problem of the recovery of such type of fastidious bacterium. Identification was achieved by molecular methods (16S rRNA sequencing). A review of the English literature found only 8 cases of bacteremia caused by B. pilosicoli, mostly in immunocompromised or critically ill patients. Finally, difficulties in rapid and accurate diagnosis of B. pilosicoli bloodstream infections, in vitro antimicrobial susceptibility of human clinical isolates, and therapeutic options are discussed.
Predicting the sensitivity and specificity of published real-time PCR assays
Gordon H Lemmon and Shea N Gardner Thu, 25 Sep 2008 00:00:00 -0000
Background: In recent years real-time PCR has become a leading technique for nucleic acid detection and quantification. These assays have the potential to greatly enhance efficiency in the clinical laboratory. Choice of primer and probe sequences is critical for accurate diagnosis in the clinic, yet current primer/probe signature design strategies are limited, and signature evaluation methods are lacking. Methods: We assessed the quality of a signature by predicting the number of true positive, false positive and false negative hits against all available public sequence data. We found real-time PCR signatures described in recent literature and used a BLAST search based approach to collect all hits to the primer-probe combinations that should be amplified by real-time PCR chemistry. We then compared our hits with the sequences in the NCBI taxonomy tree that the signature was designed to detect. Results: We found that many published signatures have high specificity (almost no false positives) but low sensitivity (high false negative rate). Where high sensitivity is needed, we offer a revised methodology for signature design which may designate that multiple signatures are required to detect all sequenced strains. We use this methodology to produce new signatures that are predicted to have higher sensitivity and specificity. Conclusion: We show that current methods for real-time PCR assay design have unacceptably low sensitivities for most clinical applications. Additionally, as new sequence data becomes available, old assays must be reassessed and redesigned. A standard protocol for both generating and assessing the quality of these assays is therefore of great value. Real-time PCR has the capacity to greatly improve clinical diagnostics. The improved assay design and evaluation methods presented herein will expedite adoption of this technique in the clinical lab.
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Permanent Pathology Job in Las Cruces New Mexico with Community Health Systems
Join a private practice in Las Cruces NM. Las Cruces is a beautiful and growing community, nestled in the mountains and mesas of southern New Mexico. Located just 45 minutes away is El Paso International
Permanent Pathology Job in Riverton Wyoming with Riverton Memorial Hospital
Physician Pathology Beautiful Wyoming Wind River Country Seeking a pathologist for 70 bed hospital. Surgical specialties: orthopedics, ent, ophthalmology, general surgery, bariatric surgery, urology,
Locum Tenens Pathology Job in Florham Park New Jersey with Medical Search International
Great $$$-BC/BE Pathologist-Locum Tenens-Northern New Jersey Seeking a BC/BE Pathologist for a Locum Tenens assignment in New Jersey. 90-180 days (may be extended). This position may be converted to
Annals of Clinical Microbiology and Antimicrobials - Latest articles
Pitfalls in efficacy testing – how important is the validation of neutralization of chlorhexidine digluconate?
Mirja Reichel, Peter Heisig and Günter Kampf Tue, 02 Dec 2008 00:00:00 -0000
Background: Effective neutralization of active agents is essential to obtain valid efficacy results, especially when non-volatile active agents like chlorhexidine digluconate (CHG) are tested. The aim of this study was to determine an effective and non-toxic neutralizing mixture for a propan-1-ol solution containing 2% CHG. Methods: Experiments were carried out according to ASTM E 1054-02. The neutralization capacity was tested separately with five challenge microorganisms in suspension, and with a rayon swab carrier. Either 0.5 mL of the antiseptic solution (suspension test) or a saturated swab with the antiseptic solution (carrier test) was added to tryptic soy broth containing neutralizing agents. After the samples were mixed, aliquots were spread immediately and after 3 h of storage at 2 – 8°C onto tryptic soy agar containing a neutralizing mixture. Results: The neutralizer was, however, not consistently effective in the suspension test. Immediate spread yielded a valid neutralization with Staphylococcus aureus, Staphylococcus epidermidis and Corynebacterium jeikeium but not with Micrococcus luteus (p < 0.001) and Candida albicans (p < 0.001). A 3-h storage period of the neutralized active agents in suspension resulted in significant carry-over activity of CHG in addition against Staphylococcus epidermidis (p < 0.001) and Corynebacterium jeikeium (p = 0.044). In the carrier test, the neutralizing mixture was found to be effective and non toxic to all challenge microorganisms when spread immediately. However, after 3 h storage of the neutralized active agents significant carry-over activity of CHG against Micrococcus luteus (p = 0.004; Tukey HSD) was observed. Conclusion: Without effective neutralization in the sampling fluid, non-volatile active ingredients will continue to reduce the number of surviving microorganisms after antiseptic treatment even if the sampling fluid is kept cold straight after testing. This can result in false-positive antiseptic efficacy data. Attention should be paid during the neutralization validation process to the amount of antiseptic solution, the storage time and to the choice of appropriate and sensitive microorganisms.
Brachyspira pilosicoli bloodstream infections: Case report and review of the literature
Lilia Bait-Merabet, Arnaud Thille, Patrick Legrand, Christian Brun-Buisson and Vincent Cattoir Thu, 25 Sep 2008 00:00:00 -0000
Brachyspira pilosicoli is the etiologic agent of human and animal intestinal spirochetosis and is rarely implicated as a cause of bacteremia. Here, we describe the case of a B. pilosicoli spirochetemia in a 53-year-old male patient suffering from cardiogenic shock. This fastidious bacterium was isolated from blood, likely after translocation from the intestinal tract. Blood cultures were positive after 5 days of incubation (one day after the patient's death), highlighting the problem of the recovery of such type of fastidious bacterium. Identification was achieved by molecular methods (16S rRNA sequencing). A review of the English literature found only 8 cases of bacteremia caused by B. pilosicoli, mostly in immunocompromised or critically ill patients. Finally, difficulties in rapid and accurate diagnosis of B. pilosicoli bloodstream infections, in vitro antimicrobial susceptibility of human clinical isolates, and therapeutic options are discussed.
Predicting the sensitivity and specificity of published real-time PCR assays
Gordon H Lemmon and Shea N Gardner Thu, 25 Sep 2008 00:00:00 -0000
Background: In recent years real-time PCR has become a leading technique for nucleic acid detection and quantification. These assays have the potential to greatly enhance efficiency in the clinical laboratory. Choice of primer and probe sequences is critical for accurate diagnosis in the clinic, yet current primer/probe signature design strategies are limited, and signature evaluation methods are lacking. Methods: We assessed the quality of a signature by predicting the number of true positive, false positive and false negative hits against all available public sequence data. We found real-time PCR signatures described in recent literature and used a BLAST search based approach to collect all hits to the primer-probe combinations that should be amplified by real-time PCR chemistry. We then compared our hits with the sequences in the NCBI taxonomy tree that the signature was designed to detect. Results: We found that many published signatures have high specificity (almost no false positives) but low sensitivity (high false negative rate). Where high sensitivity is needed, we offer a revised methodology for signature design which may designate that multiple signatures are required to detect all sequenced strains. We use this methodology to produce new signatures that are predicted to have higher sensitivity and specificity. Conclusion: We show that current methods for real-time PCR assay design have unacceptably low sensitivities for most clinical applications. Additionally, as new sequence data becomes available, old assays must be reassessed and redesigned. A standard protocol for both generating and assessing the quality of these assays is therefore of great value. Real-time PCR has the capacity to greatly improve clinical diagnostics. The improved assay design and evaluation methods presented herein will expedite adoption of this technique in the clinical lab.
Sites:
Cambridge University : Pathology: The Department of Pathology is one of the largest Departments in the School of Biological Sciences. Its reputation for outstanding academic achievement is known world-wide and reflects the intellectual achievement of its students, as well as the world-class original research carried out by the...Cornell : Pathology and Laboratory Medicine: Provides teaching for medical students as well as academic research, clinical pathology and consulting services. Includes program and outreach information and a hematopthology tutorial.
Dalhousie University : Pathology: The study of Pathology encompasses the understanding of basic responses of cells, tissues and organs to various injurious stimuli with particular emphasis on the role of such responses in the pathogenesis of inflammatory responses, neoplasia, fluid and hemodynamic derangements.
Dartmouth-Hitchcock Medical Center : Pathology: This faculty in New Hampshire provides monthly case histories and illustrated lectures.
Eastern Virginia Medical School : Pathology and Anatomy: Offers courses for medical, physician assistant, and graduate students in gross anatomy, histology, neuroscience, and pathology. Information on programs, facilities and research.
George Washington University : Pathology: George Washington University Medical School - Pathology Department
Johns Hopkins University : Pathology: Johns Hopkins Department of Pathology
New York Medical College : Pathology: Pathology programs.PhD and MS graduate degrees in experimental pathology, teaching, medical residency and postdoctoral fellowships in research of the pathogenesis of human disease. Graduates work in industry, government, academia.
New York University : Pathology: Information about education and research activities.
Nottingham University : Pathology: Provides undergraduate teaching and research into neurodegenerative diseases and the pathology and clinical management of patients with breast cancer.
Ohio State University : Pathology: The Ohio State University Department of Pathology is a basic science department with a full graduate program leading to both a Masters and a Ph.D in pathology and laboratory medicine.
Oregon Health and Science University : Pathology: Detailed information on pathology, the study of disease
Pennsylvania State University : Pathology and Laboratory Medicine: Penn State Pathology specialty areas in clinical pathology include donor and transfusion services, clinical chemistry, clinical toxicology, hematology and coagulation studies, histo-compatibility, microbiology and virology, radio-immunoassay studies, and cytogenics.
Poznan University : Pathology: Offering undergraduate teaching for students of Medicine and Dentistry, as well as masters' and doctoral programs and research. Details of staff and courses, with information on telepathology. In Polish and English.
Thomas Jefferson University : Pathology, Anatomy and Cell Biology: Thomas Jefferson University, Philadelphia's premier medical and health sciences university, offers quality education to future physicians, nurses, scientists and allied health professionals who will take a leadership role in healthcare.
Tulane University : Pathology and Laboratory Medicine: Providing medical and graduate courses as well as cliniical laboratory services. Details of programs and staff, a conference calendar and information on testing facilities.
University of Alberta : Laboratory Medicine and Pathology: Providing courses for students in Medicine, Dentistry, Pharmacy, Nursing and Rehabilitation Medicine. Details of teaching and research programs.
University of Arizona : Pathology: Provides education, research, quality control and laboratory services for the university. Details of residency and telemedicine programs.
University of Arkansas : Pathology: Offersfellowship and residency programs and undergraduate teaching through the medical school. Course details, research information and staff profiles.
University of California, Los Angeles : Pathology and Laboratory Medicine: Providing graduate and undergraduate courses, clinical services and research programs. Includes information on teaching, referral services and the medical school.
University of California, San Francisco : Pathology: Offering residency, fellowship and programs, plus clinical and consultative services.
University of Cincinnati : Pathology and Laboratory Medicine: Providing undergraduate and graduate teaching and consultative services. Details of courses, research projects and staff.
University of Erlangen : Pathology: A weekly case is presented, as well as a gallery of frozen sections with clinical details, diagnoses and comments. Fürth, Germany.
University of Florence : Clinical Physiopathology: ,
University of Florida : Pathology, Immunology and Laboratory Medicine: The Dept of Pathology is in the Cohllege of Medicine of the University of Florida located in Gainesville, Florida, USA. This is the main entry point for the office departmental web pages.
University of Harvard : Pathology: Offering training within the Medical School as well as research in the fields of neuropathology and cancer. Includes program details and seminar information.
University of Iowa : Pathology: The University of Iowa Department of Pathology Homepage
University of Leicester : Pathology: Home page for the Clinical Division of Pathology at the University of Leicester, UK
University of Melbourne : Pathology: [Public, Home Page] The home page of the Department of Pathology at The University of Melbourne.
University of Michigan : Pathology: The official website for the Department of Pathology (including M-Labs) at the University of Michigan in Ann Arbor, MI.
University of Milan : Pathology: Offers undergraduate teaching for students of Medicine and Surgery, as well as residency and doctoral programmes. Includes details of research into Sudden Infant Death Syndrome and cardiac conditions. In Italian and English.
University of Nebraska : Pathology and Microbiology: Information about clinical services, education, research and seminars.
University of North Carolina : Pathology and Laboratory Medicine: Offers graduate programs in molecular, cellular and environmental pathology, as well as a forensic fellowship. Details of courses, services and staff.
University of North Carolina : Pathology and Laboratory Medicine: Offering a residency program in anatomic and clinical pathology, and graduate programs in molecular and cellular pathology. Course details and a calendar of grand rounds and seminars.
University of Oxford : Pathology: Head of Department: Herman Waldmann
University of Pittsburgh : Pathology: Educational information, online courses, a case of the month, databases and resources.
University of Rochester : Pathology and Laboratory Medicine: Welcome to the Department of Pathology and Laboratory Medicine home page at the University of Rochester Medical Center. The Department is responsible for the operation of the Strong Health Clinical Laboratories, educational programs in pathology, and research in the cellular and molecular pathol...
University of Sheffield: Forensic Pathology: Providing services, specialist consultancy, research and postgraduate teaching.
University of Southern California : Pathology: Offers undergraduate, residency and research programs as well as diagnostic laboratory services. Information on education, training, clinical activities and research.
University of Tennessee Graduate School of Medicine : Pathology: The University of Tennessee, Knoxville was founded in 1794 and was designated the state land-grant institution in 1879. The University now has nearly 26,000 students and 400 academic programs.
University of Tennessee Health Science Center : Pathology and Laboratory Medicine: The University of Tennessee, Knoxville was founded in 1794 and was designated the state land-grant institution in 1879. The University now has nearly 26,000 students and 400 academic programs.
University of Texas : Pathology and Laboratory Medicine: Home page for the department of pathology and laboratory medicine
University of Vermont : Pathology and Laboratory Medicine: Offering education, research and training programs as well as diagnostic services. Details of courses, conferences, staff and publications.
University of Virginia : Pathology: pathology
University of Washington : Pathology: Information on the University of Washington and the Department of Patholgy. Includes informative description of breakdown of departments as well as employees. This site also includes galleries of various images in the field of pathology.
University of Wisconsin : Pathology and Laboratory Medicine: Academic, research, and clinical resources for current and prospective students, researchers, and visitors
University of Zurich : Pathology: Diagnostics, Research and Training, Diagnostik, Forschung und Lehre
Virginia Commonwealth University : Pathology: Providing clinical, research, and teaching services. Details of research programs and clinical laboratories, with information on grand rounds.
Wake Forest University : Pathology: , Pathology
Washington University: Pathology and Immunology: Information on residency training and clinical fellowships.
Yale University : Pathology: Offering programmes for post-doctoral fellows, medical and graduate student, as well as diagnostic anatomic pathology services and research. Course details, meetings calendar and live video microscopy.
This directory is based on the Open Directory and may have been modified