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Locum Tenens Pathology Job in Pathology Christmas Coverage Pennsylvania with CompHealth Inc
Job 1183660-0023 AP/CP Community Based Hospital Lab Call Please call for details We offer competitive pay that may include incentives and bonuses We coordinate and pay for your travel, housing, and
Locum Tenens Pathology Job in Surgical Pathologist Mississippi with CompHealth Inc
Job 1228885-0024 AP/CP Monday - Friday, 8:00 a.m. - 5:00 p.m. No Call Please Call for Details We offer competitive pay that may include incentives and bonuses We coordinate and pay for your travel,
Locum Tenens Pathology Job in Locums Needed for Solo Practice South Dakota with CompHealth Inc
Job 1353913-0011 Hospital based, Monday through Friday. No call. No paps, but must be comfortable with non-gyn cytology. Frozens required. Please call for additional details. We offer competitive pay
Annals of Clinical Microbiology and Antimicrobials - Latest articles
Brachyspira pilosicoli bloodstream infections: Case report and review of the literature
Lilia Bait-Merabet, Arnaud Thille, Patrick Legrand, Christian Brun-Buisson and Vincent Cattoir Thu, 25 Sep 2008 00:00:00 -0000
Brachyspira pilosicoli is the etiologic agent of human and animal intestinal spirochetosis and is rarely implicated as a cause of bacteremia. Here, we describe the case of a B. pilosicoli spirochetemia in a 53-year-old male patient suffering from cardiogenic shock. This fastidious bacterium was isolated from blood, likely after translocation from the intestinal tract. Blood cultures were positive after 5 days of incubation (one day after the patient's death), highlighting the problem of the recovery of such type of fastidious bacterium. Identification was achieved by molecular methods (16S rRNA sequencing). A review of the English literature found only 8 cases of bacteremia caused by B. pilosicoli, mostly in immunocompromised or critically ill patients. Finally, difficulties in rapid and accurate diagnosis of B. pilosicoli bloodstream infections, in vitro antimicrobial susceptibility of human clinical isolates, and therapeutic options are discussed.
Predicting the sensitivity and specificity of published real-time PCR assays
Gordon H Lemmon and Shea N Gardner Thu, 25 Sep 2008 00:00:00 -0000
Background: In recent years real-time PCR has become a leading technique for nucleic acid detection and quantification. These assays have the potential to greatly enhance efficiency in the clinical laboratory. Choice of primer and probe sequences is critical for accurate diagnosis in the clinic, yet current primer/probe signature design strategies are limited, and signature evaluation methods are lacking. Methods: We assessed the quality of a signature by predicting the number of true positive, false positive and false negative hits against all available public sequence data. We found real-time PCR signatures described in recent literature and used a BLAST search based approach to collect all hits to the primer-probe combinations that should be amplified by real-time PCR chemistry. We then compared our hits with the sequences in the NCBI taxonomy tree that the signature was designed to detect. Results: We found that many published signatures have high specificity (almost no false positives) but low sensitivity (high false negative rate). Where high sensitivity is needed, we offer a revised methodology for signature design which may designate that multiple signatures are required to detect all sequenced strains. We use this methodology to produce new signatures that are predicted to have higher sensitivity and specificity. Conclusion: We show that current methods for real-time PCR assay design have unacceptably low sensitivities for most clinical applications. Additionally, as new sequence data becomes available, old assays must be reassessed and redesigned. A standard protocol for both generating and assessing the quality of these assays is therefore of great value. Real-time PCR has the capacity to greatly improve clinical diagnostics. The improved assay design and evaluation methods presented herein will expedite adoption of this technique in the clinical lab.
Antimicrobial activity of some sulfonamide derivatives on clinical isolates of Staphylococus aureus
Yeliz Genç, Reşit Özkanca and Yunus Bekdemir Wed, 20 Aug 2008 00:00:00 -0000
Background: Staphylococcus aureus is a non-motile, gram positive, non-sporforming, facultative anaerobic microorganism. It is one of the important bacteria as a potential pathogen specifically for nosocomial infections. The sulfonamide derivative medicines are preferred to cure infection caused by S. aureus due to methicillin resistance. Methods: Antimicrobial activity of four sulfonamide derivatives have been investigated against 50 clinical isolates of S. aureus and tested by using MIC and disc diffusion methods. 50 clinical isolate which collected from specimens of patients who are given medical treatment in Ondokuz Mayis University Medical School Hospital. A control strain of S. aureus ATCC 29213 was also tested. Results: The strongest inhibition was observed in the cases of I [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid], and II [N-(2-hydroxy-5-nitro-phenyl)-4-methyl-benzensulfonamid] against S. aureus. Compound I [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid] showed higher effect on 21 S. aureus MRSAisolates than oxacillin antibiotic. Introducing an electron withdrawing on the ring increased the antimicrobial activity remarkably. Conclusion: This study may help to suggest an alternative possible leading compound for development of new antimicrobial agents against MRSA and MSSA resistant S. aureus. It was also shown here that that clinical isolates of 50 S. aureus have various resistance patterns against to four sulfonamide derivatives. It may also be emphasized here that in vitro antimicrobial susceptibility testing results for S. aureus need standardization with further studies and it should also have a correlation with in vivo therapeutic response experiments.
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Locum Tenens Pathology Job in Pathology Christmas Coverage Pennsylvania with CompHealth Inc
Job 1183660-0023 AP/CP Community Based Hospital Lab Call Please call for details We offer competitive pay that may include incentives and bonuses We coordinate and pay for your travel, housing, and
Locum Tenens Pathology Job in Surgical Pathologist Mississippi with CompHealth Inc
Job 1228885-0024 AP/CP Monday - Friday, 8:00 a.m. - 5:00 p.m. No Call Please Call for Details We offer competitive pay that may include incentives and bonuses We coordinate and pay for your travel,
Locum Tenens Pathology Job in Locums Needed for Solo Practice South Dakota with CompHealth Inc
Job 1353913-0011 Hospital based, Monday through Friday. No call. No paps, but must be comfortable with non-gyn cytology. Frozens required. Please call for additional details. We offer competitive pay
Annals of Clinical Microbiology and Antimicrobials - Latest articles
Brachyspira pilosicoli bloodstream infections: Case report and review of the literature
Lilia Bait-Merabet, Arnaud Thille, Patrick Legrand, Christian Brun-Buisson and Vincent Cattoir Thu, 25 Sep 2008 00:00:00 -0000
Brachyspira pilosicoli is the etiologic agent of human and animal intestinal spirochetosis and is rarely implicated as a cause of bacteremia. Here, we describe the case of a B. pilosicoli spirochetemia in a 53-year-old male patient suffering from cardiogenic shock. This fastidious bacterium was isolated from blood, likely after translocation from the intestinal tract. Blood cultures were positive after 5 days of incubation (one day after the patient's death), highlighting the problem of the recovery of such type of fastidious bacterium. Identification was achieved by molecular methods (16S rRNA sequencing). A review of the English literature found only 8 cases of bacteremia caused by B. pilosicoli, mostly in immunocompromised or critically ill patients. Finally, difficulties in rapid and accurate diagnosis of B. pilosicoli bloodstream infections, in vitro antimicrobial susceptibility of human clinical isolates, and therapeutic options are discussed.
Predicting the sensitivity and specificity of published real-time PCR assays
Gordon H Lemmon and Shea N Gardner Thu, 25 Sep 2008 00:00:00 -0000
Background: In recent years real-time PCR has become a leading technique for nucleic acid detection and quantification. These assays have the potential to greatly enhance efficiency in the clinical laboratory. Choice of primer and probe sequences is critical for accurate diagnosis in the clinic, yet current primer/probe signature design strategies are limited, and signature evaluation methods are lacking. Methods: We assessed the quality of a signature by predicting the number of true positive, false positive and false negative hits against all available public sequence data. We found real-time PCR signatures described in recent literature and used a BLAST search based approach to collect all hits to the primer-probe combinations that should be amplified by real-time PCR chemistry. We then compared our hits with the sequences in the NCBI taxonomy tree that the signature was designed to detect. Results: We found that many published signatures have high specificity (almost no false positives) but low sensitivity (high false negative rate). Where high sensitivity is needed, we offer a revised methodology for signature design which may designate that multiple signatures are required to detect all sequenced strains. We use this methodology to produce new signatures that are predicted to have higher sensitivity and specificity. Conclusion: We show that current methods for real-time PCR assay design have unacceptably low sensitivities for most clinical applications. Additionally, as new sequence data becomes available, old assays must be reassessed and redesigned. A standard protocol for both generating and assessing the quality of these assays is therefore of great value. Real-time PCR has the capacity to greatly improve clinical diagnostics. The improved assay design and evaluation methods presented herein will expedite adoption of this technique in the clinical lab.
Antimicrobial activity of some sulfonamide derivatives on clinical isolates of Staphylococus aureus
Yeliz Genç, Reşit Özkanca and Yunus Bekdemir Wed, 20 Aug 2008 00:00:00 -0000
Background: Staphylococcus aureus is a non-motile, gram positive, non-sporforming, facultative anaerobic microorganism. It is one of the important bacteria as a potential pathogen specifically for nosocomial infections. The sulfonamide derivative medicines are preferred to cure infection caused by S. aureus due to methicillin resistance. Methods: Antimicrobial activity of four sulfonamide derivatives have been investigated against 50 clinical isolates of S. aureus and tested by using MIC and disc diffusion methods. 50 clinical isolate which collected from specimens of patients who are given medical treatment in Ondokuz Mayis University Medical School Hospital. A control strain of S. aureus ATCC 29213 was also tested. Results: The strongest inhibition was observed in the cases of I [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid], and II [N-(2-hydroxy-5-nitro-phenyl)-4-methyl-benzensulfonamid] against S. aureus. Compound I [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid] showed higher effect on 21 S. aureus MRSAisolates than oxacillin antibiotic. Introducing an electron withdrawing on the ring increased the antimicrobial activity remarkably. Conclusion: This study may help to suggest an alternative possible leading compound for development of new antimicrobial agents against MRSA and MSSA resistant S. aureus. It was also shown here that that clinical isolates of 50 S. aureus have various resistance patterns against to four sulfonamide derivatives. It may also be emphasized here that in vitro antimicrobial susceptibility testing results for S. aureus need standardization with further studies and it should also have a correlation with in vivo therapeutic response experiments.
Sites:
What is Pathology ?: A consumer guide, including how to understand a pathology report and the process undertaken to reach a diagnosis.Armed Forces Institute of Pathology: An agency of the United States Department of Defense offering consultation, education and research. Details of services and resources, and a list of publications.
Atlas of Gastrointestinal Endoscopy: Images of diseased tissue throughout the tract, including tumours, ulcers and inflammatory bowel disease.
Atlas of Neuro-Oncology: ANOCEF's Atlas of Neuro-Oncology
Fibroblast Biology and Pathology at BioBitField: Information on research into the causes and treatment of fibrosis and scleroderma.
Indiana University : Pathology Education Resources: PerlJam is the product of the Pathology Education Resources Laboratory of the Department of Pathology at Indiana University School of Medicine. The site is intended to provide instructional support for medical and graduate students studying Histology and Pathology. Student evaluated links are ...
International Symposium on Comparative Pathology: An annual event under the auspices of the European Society of Pathology and the Academy of Medical Sciences of Croatia. Details of the next meeting and photographs of previous ones.
Museum of Human Disease: The Museum of Human Disease is located within the Department of Pathology in the Faculty of Medicine at the University of New South Wales in Sydney, Australia. The Museum contains over 2,700 specimens of diseased human tissue. Selected images of these specimens have been hotspotted to allow inter...
Nephropathology Biopsy Cases: Each includes a clinical history, photomicrographs, pathologic diagnosis, and discussion.
Online Interactive Pathology Laboratory: Offers an interactive, case-based approach to learning.
PathMax: PathMax is the premiere pathologist-created WWW metaindex of sites pertinent to pathology education. PathMax is indexed by topic and constantly updated and reviewed by pathology professionals.
Pathology jobs: Pathology jobs are listed at Physician Employment. You may register to be automatically updated when new jobs are listed.
Pathology Jobs: Physician jobs for all specialties throughout North America.
Pathology Quiz Online: Presents a series of illustrated case histories.
Pathologynet: An interactive information center about pathology and medical laboratory. Provides pathology news, numerous links (including employment, conference & industry), forum, polls, quiz and a career guide.
PathWeb: the Virtual Pathology Museum, Department of Pathology, University of Connecticut Health Center
The Internet Pathology Laboratory: WebPath contains images, text, and tutorials for pathology education
The Pathology Guy: General topics are discussed, as well as articles on autopsies, evidence collection and other forensic issues.
Transplant Pathology Internet Services: International collaboration on standardizing criteria for assessing the histopathologic features of rejection. Provides photographic case histories and discussion.
University Pathologists: Provides cytology and tissue diagnostic services for head and neck, upper and lower respiratory tract, breast, gastrointestinal, endocrine, urologic, hematopoietic and cutaneous pathology. Find details for professionals and patients.
Urbana Atlas of Pathology: Images cover all body systems and disease processes.
Virtual Hospital : Pathology Textbooks: Virtual Hospital was a digital library of health information in pediatrics, paediatrics, and radiology for pediatric education and radiology education
Wellpath: Electroninc Learning Environmet in Pathology. Used in life-long learning, distance and conventional education in University of Oviedo
This directory is based on the Open Directory and may have been modified