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Permanent Nuclear Medicine Job in Statewide Pennsylvania with The Doctor Job
Looking for a job in a big city? Even if you've heard that a market is "saturated", wecan help! Many job openings for physicians may be hidden and unavailable unless you knowwhere to
Permanent Nuclear Medicine Job in Statewide Virginia with The Doctor Job
Looking for a job in a big city? Even if you've heard that a market is "saturated", we can help! Many job openings for physicians may be hidden and unavailable unless you know where to look. An excellent
Permanent Nuclear Medicine Job in Statewide Texas with The Doctor Job
Looking for a job in a big city? Even if you've heard that a market is "saturated", we can help! Many job openings for physicians may be hidden and unavailable unless you know where to look. An excellent
PubMed: 0161-5505
Comparison between adenoviral and retroviral vectors for the transduction of the thymidine kinase PET reporter gene in rat mesenchymal stem cells.
Roelants V, Labar D, de Meester C, Havaux X, Tabilio A, Gambhir SS, Di Ianni M, Bol A, Bertrand L, Vanoverschelde JL Related Articles Comparison between adenoviral and retroviral vectors for the transduction of the thymidine kinase PET reporter gene in rat mesenchymal stem cells. J Nucl Med. 2008 Nov;49(11):1836-44 Authors: Roelants V, Labar D, de Meester C, Havaux X, Tabilio A, Gambhir SS, Di Ianni M, Bol A, Bertrand L, Vanoverschelde JL Mesenchymal stem cells (MSCs) are a promising cell line for the treatment of ischemic heart disease. To evaluate the success of their transplantation into living animals, noninvasive imaging techniques that are able to track the distribution and fate of those cells would be useful. The aim of this study was to investigate the feasibility of infecting rat MSCs with adenoviruses and retroviruses carrying the herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene; to compare the level of transgene expression induced by the 2 viral vectors; to evaluate the effects of viral transduction on cell phenotype, viability, proliferation rates, and differentiation capabilities; and to test the possibility of noninvasively imaging transduced MSCs using 9-(4-18F-fluoro-3-[hydroxymethyl]butyl)guanine (18F-FHBG) and small-animal PET after their transplantation into living rats. METHODS: We infected rat bone marrow MSCs with adenoviruses carrying the HSV1 mutant tk (Ad-HSV1-sr39tk) PET reporter gene (PRG) or with a retroviral construct expressing the wild-type HSV1-tk PRG. The efficacy and intensity of HSV1-sr39tk and HSV1-tk gene expression were determined by a direct comparison of [8-3H]-penciclovir ([8-3H]-PCV) cell uptake in both infected MSC populations and noninfected control MSCs. Small-animal PET studies were performed on living rats after an intramuscular injection of infected MSCs. The MSCs either have been incubated in advance with 18F-FHBG or were administered after an intravenous injection of 18F-FHBG. RESULTS: Both adenoviral and retroviral vectors can be used to introduce the tk PRG in MSCs. Neither adenovirus nor retrovirus infections significantly modify MSC phenotype, viability, proliferation, and differentiation capabilities. No significant 3H-PCV uptake was observed in noninfected MSCs. By contrast, after both adenoviral and retroviral infections, the infected MSC populations exhibited a similar, significantly higher, 3H-PCV accumulation. Small-animal PET images showed intense activity within the transplanted regions irrespective of the infected MSC population used. CONCLUSION: Our results demonstrate the feasibility of infecting MSCs with adenoviruses and retroviruses expressing the HSV1-tk PRG and suggest that infected MSCs can be noninvasively imaged with 18F-FHBG and small-animal PET after their transplantation into living animals. PMID: 18984872 [PubMed - indexed for MEDLINE]
To PIOPED, or not to PIOPED.
Reinartz P Related Articles To PIOPED, or not to PIOPED. J Nucl Med. 2008 Nov;49(11):1739-40 Authors: Reinartz P PMID: 18927343 [PubMed - indexed for MEDLINE]
MIRD pamphlet No. 20: the effect of model assumptions on kidney dosimetry and response--implications for radionuclide therapy.
Wessels BW, Konijnenberg MW, Dale RG, Breitz HB, Cremonesi M, Meredith RF, Green AJ, Bouchet LG, Brill AB, Bolch WE, Sgouros G, Thomas SR Related Articles MIRD pamphlet No. 20: the effect of model assumptions on kidney dosimetry and response--implications for radionuclide therapy. J Nucl Med. 2008 Nov;49(11):1884-99 Authors: Wessels BW, Konijnenberg MW, Dale RG, Breitz HB, Cremonesi M, Meredith RF, Green AJ, Bouchet LG, Brill AB, Bolch WE, Sgouros G, Thomas SR Renal toxicity associated with small-molecule radionuclide therapy has been shown to be dose-limiting for many clinical studies. Strategies for maximizing dose to the target tissues while sparing normal critical organs based on absorbed dose and biologic response parameters are commonly used in external-beam therapy. However, radiopharmaceuticals passing though the kidneys result in a differential dose rate to suborgan elements, presenting a significant challenge in assessing an accurate dose-response relationship that is predictive of toxicity in future patients. We have modeled the multiregional internal dosimetry of the kidneys combined with the biologic response parameters based on experience with brachytherapy and external-beam radiation therapy to provide an approach for predicting radiation toxicity to the kidneys. METHODS: The multiregion kidney dosimetry model of MIRD pamphlet no. 19 has been used to calculate absorbed dose to regional structures based on preclinical and clinical data. Using the linear quadratic model for radiobiologic response, we computed regionally based surviving fractions for the kidney cortex and medulla in terms of their concentration ratios for several examples of radiopharmaceutical uptake and clearance. We used past experience to illustrate the relationship between absorbed dose and calculated biologically effective dose (BED) with radionuclide-induced nephrotoxicity. RESULTS: Parametric analysis for the examples showed that high dose rates associated with regions of high activity concentration resulted in the greatest decrease in tissue survival. Higher dose rates from short-lived radionuclides or increased localization of radiopharmaceuticals in radiosensitive kidney subregions can potentially lead to greater whole-organ toxicity. This finding is consistent with reports of kidney toxicity associated with early peptide receptor radionuclide therapy and (166)Ho-phosphonate clinical investigations. CONCLUSION: Radionuclide therapy dose-response data, when expressed in terms of biologically effective dose, have been found to be consistent with external-beam experience for predicting kidney toxicity. Model predictions using both the multiregion kidney and linear quadratic models may serve to guide the investigator in planning and optimizing future clinical trials of radionuclide therapy. PMID: 18927342 [PubMed - indexed for MEDLINE]
Nuclear Medicine Communications - Current Table Of Contents
Editors' report.
Page: 1DOI: 10.1097/MNM.0b013e328321e041
Advanced head and neck cancer: is there a role for fluorodeoxyglucose PET/computed tomography?
Page: 2DOI: 10.1097/MNM.0b013e32831a9aacAuthors: Wong, Wai Lup a; Nutting, Chris b; Dunn, Janet c; Fisher, Sheila d; MacLennan, Ken d; MacCabe, Chris d; Mehanna, Hisham e
Radiolabeled immunotherapy in non-Hodgkin's lymphoma treatment: the next step.
Page: 5DOI: 10.1097/MNM.0b013e328313e565Authors: Otte, Andreas a b; van de Wiele, Christophe b; Dierckx, Rudi A. c
PubMed: 1532-6551
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Permanent Nuclear Medicine Job in Statewide Pennsylvania with The Doctor Job
Looking for a job in a big city? Even if you've heard that a market is "saturated", wecan help! Many job openings for physicians may be hidden and unavailable unless you knowwhere to
Permanent Nuclear Medicine Job in Statewide Virginia with The Doctor Job
Looking for a job in a big city? Even if you've heard that a market is "saturated", we can help! Many job openings for physicians may be hidden and unavailable unless you know where to look. An excellent
Permanent Nuclear Medicine Job in Statewide Texas with The Doctor Job
Looking for a job in a big city? Even if you've heard that a market is "saturated", we can help! Many job openings for physicians may be hidden and unavailable unless you know where to look. An excellent
PubMed: 0161-5505
Comparison between adenoviral and retroviral vectors for the transduction of the thymidine kinase PET reporter gene in rat mesenchymal stem cells.
Roelants V, Labar D, de Meester C, Havaux X, Tabilio A, Gambhir SS, Di Ianni M, Bol A, Bertrand L, Vanoverschelde JL Related Articles Comparison between adenoviral and retroviral vectors for the transduction of the thymidine kinase PET reporter gene in rat mesenchymal stem cells. J Nucl Med. 2008 Nov;49(11):1836-44 Authors: Roelants V, Labar D, de Meester C, Havaux X, Tabilio A, Gambhir SS, Di Ianni M, Bol A, Bertrand L, Vanoverschelde JL Mesenchymal stem cells (MSCs) are a promising cell line for the treatment of ischemic heart disease. To evaluate the success of their transplantation into living animals, noninvasive imaging techniques that are able to track the distribution and fate of those cells would be useful. The aim of this study was to investigate the feasibility of infecting rat MSCs with adenoviruses and retroviruses carrying the herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene; to compare the level of transgene expression induced by the 2 viral vectors; to evaluate the effects of viral transduction on cell phenotype, viability, proliferation rates, and differentiation capabilities; and to test the possibility of noninvasively imaging transduced MSCs using 9-(4-18F-fluoro-3-[hydroxymethyl]butyl)guanine (18F-FHBG) and small-animal PET after their transplantation into living rats. METHODS: We infected rat bone marrow MSCs with adenoviruses carrying the HSV1 mutant tk (Ad-HSV1-sr39tk) PET reporter gene (PRG) or with a retroviral construct expressing the wild-type HSV1-tk PRG. The efficacy and intensity of HSV1-sr39tk and HSV1-tk gene expression were determined by a direct comparison of [8-3H]-penciclovir ([8-3H]-PCV) cell uptake in both infected MSC populations and noninfected control MSCs. Small-animal PET studies were performed on living rats after an intramuscular injection of infected MSCs. The MSCs either have been incubated in advance with 18F-FHBG or were administered after an intravenous injection of 18F-FHBG. RESULTS: Both adenoviral and retroviral vectors can be used to introduce the tk PRG in MSCs. Neither adenovirus nor retrovirus infections significantly modify MSC phenotype, viability, proliferation, and differentiation capabilities. No significant 3H-PCV uptake was observed in noninfected MSCs. By contrast, after both adenoviral and retroviral infections, the infected MSC populations exhibited a similar, significantly higher, 3H-PCV accumulation. Small-animal PET images showed intense activity within the transplanted regions irrespective of the infected MSC population used. CONCLUSION: Our results demonstrate the feasibility of infecting MSCs with adenoviruses and retroviruses expressing the HSV1-tk PRG and suggest that infected MSCs can be noninvasively imaged with 18F-FHBG and small-animal PET after their transplantation into living animals. PMID: 18984872 [PubMed - indexed for MEDLINE]
To PIOPED, or not to PIOPED.
Reinartz P Related Articles To PIOPED, or not to PIOPED. J Nucl Med. 2008 Nov;49(11):1739-40 Authors: Reinartz P PMID: 18927343 [PubMed - indexed for MEDLINE]
MIRD pamphlet No. 20: the effect of model assumptions on kidney dosimetry and response--implications for radionuclide therapy.
Wessels BW, Konijnenberg MW, Dale RG, Breitz HB, Cremonesi M, Meredith RF, Green AJ, Bouchet LG, Brill AB, Bolch WE, Sgouros G, Thomas SR Related Articles MIRD pamphlet No. 20: the effect of model assumptions on kidney dosimetry and response--implications for radionuclide therapy. J Nucl Med. 2008 Nov;49(11):1884-99 Authors: Wessels BW, Konijnenberg MW, Dale RG, Breitz HB, Cremonesi M, Meredith RF, Green AJ, Bouchet LG, Brill AB, Bolch WE, Sgouros G, Thomas SR Renal toxicity associated with small-molecule radionuclide therapy has been shown to be dose-limiting for many clinical studies. Strategies for maximizing dose to the target tissues while sparing normal critical organs based on absorbed dose and biologic response parameters are commonly used in external-beam therapy. However, radiopharmaceuticals passing though the kidneys result in a differential dose rate to suborgan elements, presenting a significant challenge in assessing an accurate dose-response relationship that is predictive of toxicity in future patients. We have modeled the multiregional internal dosimetry of the kidneys combined with the biologic response parameters based on experience with brachytherapy and external-beam radiation therapy to provide an approach for predicting radiation toxicity to the kidneys. METHODS: The multiregion kidney dosimetry model of MIRD pamphlet no. 19 has been used to calculate absorbed dose to regional structures based on preclinical and clinical data. Using the linear quadratic model for radiobiologic response, we computed regionally based surviving fractions for the kidney cortex and medulla in terms of their concentration ratios for several examples of radiopharmaceutical uptake and clearance. We used past experience to illustrate the relationship between absorbed dose and calculated biologically effective dose (BED) with radionuclide-induced nephrotoxicity. RESULTS: Parametric analysis for the examples showed that high dose rates associated with regions of high activity concentration resulted in the greatest decrease in tissue survival. Higher dose rates from short-lived radionuclides or increased localization of radiopharmaceuticals in radiosensitive kidney subregions can potentially lead to greater whole-organ toxicity. This finding is consistent with reports of kidney toxicity associated with early peptide receptor radionuclide therapy and (166)Ho-phosphonate clinical investigations. CONCLUSION: Radionuclide therapy dose-response data, when expressed in terms of biologically effective dose, have been found to be consistent with external-beam experience for predicting kidney toxicity. Model predictions using both the multiregion kidney and linear quadratic models may serve to guide the investigator in planning and optimizing future clinical trials of radionuclide therapy. PMID: 18927342 [PubMed - indexed for MEDLINE]
Nuclear Medicine Communications - Current Table Of Contents
Editors' report.
Page: 1DOI: 10.1097/MNM.0b013e328321e041
Advanced head and neck cancer: is there a role for fluorodeoxyglucose PET/computed tomography?
Page: 2DOI: 10.1097/MNM.0b013e32831a9aacAuthors: Wong, Wai Lup a; Nutting, Chris b; Dunn, Janet c; Fisher, Sheila d; MacLennan, Ken d; MacCabe, Chris d; Mehanna, Hisham e
Radiolabeled immunotherapy in non-Hodgkin's lymphoma treatment: the next step.
Page: 5DOI: 10.1097/MNM.0b013e328313e565Authors: Otte, Andreas a b; van de Wiele, Christophe b; Dierckx, Rudi A. c
PubMed: 1532-6551
Sites:
Brain Perfusion SPECT - Atlas, teaching cases: 22 brain SPECT teaching cases with color SPECT images and clinical information, explanations, and slide show. Also has a general tutorial section. Free, no registration. BrighamRAD, Harvard Medical School, Boston.Crump Institute Mediabook Cases: Collection of more than a hundred clinical case studies with scan images, sorted by Organ system, Disorder, and even Tracer/Study type. Also has a search system. Free, no registration. Crump Institute, UCLA.
Gastrointestinal Case Studies by Virtual Hospital: Virtual Hospital was a digital library of health information in pediatrics, paediatrics, and radiology for pediatric education and radiology education
Harvard JPNM teaching file: The Joint Program in Nuclear Medicine from the Nuclear Medicine Divisions of several Harvard Medical School teaching hospitals. 80 case studies to test yourself, each of which has a link to the complete case report, all comprehensive and well referenced.
Joint Program in Nuclear Medicine: Teaching File Cases from the Joint Program in Nuclear Medicine
Kansas University's Files: 30 clinical cases and 20 PET scans providing a variety of teaching points.
Mallinckrodt Institute of Radiology Files: MIR provides more than 200 cases in all areas, in both browsing and quiz form.
Myocardial Perfusion SPECT: Tutorial: 70 teaching cases with clinical information, color SPECT images, explanations, self quiz, and slide shows from Harvard Medical School, Boston.
Nuclear and SPECT Imaging: Twenty-five cases with large images, correlated with other imaging modalities and detailed case reports. From Case Western Reserve University, University Hospitals of Cleveland, and Rainbow Babies and Children's Hospital.
PET files - uhrad.com: 5 detailed clinical case studies of Positron Emission Tomography scans in a non-test format.
Radiopharmaceutical Image Library: A collection of both normal and abnormal images sorted by body system, from the University of Kentucky. Each comes with a short clinical introduction, and a summary of the image findings.
This directory is based on the Open Directory and may have been modified