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NEUROLOGICAL REVIEW: Blood Protein Signature for the Early Diagnosis of Alzheimer Disease
Britschgi, M., Wyss-Coray, T. Mon, 08 Dec 2008 00:00:00 -0000
Alzheimer disease (AD) has become one of the main health concerns for the elderly population in the United States. Current treatments target symptoms only, but several advanced clinical trials are testing new drugs that are potentially disease modifying. Because AD is still difficult to diagnose in its earliest stages and the disease process is estimated to start many years before current clinical diagnosis is made, accurate and simple diagnostic tools are urgently needed. We recently described a blood-based panel of secreted signaling proteins that distinguishes between blinded samples from patients with AD and control subjects with high accuracy. The same proteins also predicted progression to AD in preclinical patients with mild cognitive impairment several years before clinical diagnosis for AD was made. Herein, we describe these findings and discuss the potential for a more general application of our proteomic approach in understanding and diagnosing disease.Published online December 8, 2008 (doi:10.1001/archneurol.2008.530).
ORIGINAL CONTRIBUTION: Heterogeneity in Response to Interferon Beta in Patients With Multiple Sclerosis: A 3-Year Monthly Imaging Study
Chiu, A. W., Richert, N., Ehrmantraut, M., Ohayon, J., Gupta, S., Bomboi, G., Gaindh, D., Cantor, F. K., Frank, J. A., McFarland, H. F., Bagnato, F. Mon, 10 Nov 2008 00:00:00 -0000
Objectives To investigate the heterogeneity in magnetic resonance image (MRI) patterns of response to interferon beta across patients with multiple sclerosis or within an individual patient over time.Design, Setting, and Patients Fifteen patients with relapsing-remitting multiple sclerosis underwent monthly MRIs and clinical examinations (6-month pretherapy phase and 36-month therapy phase) and bimonthly neutralizing antibody tests. On each MRI, the total number of contrast-enhancing lesions was noted. Therapy MRI responders were defined as those with a reduction of 60% or more in the total number of contrast-enhancing lesions during each semester of therapy.Intervention Subcutaneous administration of interferon beta-1b, 250 µg, every other day for 3 years.Main Outcome Measure Reduction in the number of contrast-enhancing lesions.Results Eight patients (53.3%) were MRI responders and 7 (46.7%) were nonresponders. Of those 7, 3 (20.0%) had only an initial optimal reduction of the total number of contrast-enhancing lesions, 2 (13.3%) never reached an optimal response, and 2 (13.3%) had a delayed optimal response. No clear association between neutralizing antibody profile and MRI response was evident.Conclusions Multiple MRI evaluations disclose that approximately only half of the patients treated with interferon beta achieve and maintain a full response to the drug over time, although an additional small number of individuals may still restore an optimal response to the drug after an initial failure.Published online November 10, 2008 (doi:10.1001/archneur.66.1.noc80047).
ABOUT THIS JOURNAL: About This Journal
Mon, 08 Dec 2008 00:00:00 -0000
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NEUROLOGICAL REVIEW: Blood Protein Signature for the Early Diagnosis of Alzheimer Disease
Britschgi, M., Wyss-Coray, T. Mon, 08 Dec 2008 00:00:00 -0000
Alzheimer disease (AD) has become one of the main health concerns for the elderly population in the United States. Current treatments target symptoms only, but several advanced clinical trials are testing new drugs that are potentially disease modifying. Because AD is still difficult to diagnose in its earliest stages and the disease process is estimated to start many years before current clinical diagnosis is made, accurate and simple diagnostic tools are urgently needed. We recently described a blood-based panel of secreted signaling proteins that distinguishes between blinded samples from patients with AD and control subjects with high accuracy. The same proteins also predicted progression to AD in preclinical patients with mild cognitive impairment several years before clinical diagnosis for AD was made. Herein, we describe these findings and discuss the potential for a more general application of our proteomic approach in understanding and diagnosing disease.Published online December 8, 2008 (doi:10.1001/archneurol.2008.530).
ORIGINAL CONTRIBUTION: Heterogeneity in Response to Interferon Beta in Patients With Multiple Sclerosis: A 3-Year Monthly Imaging Study
Chiu, A. W., Richert, N., Ehrmantraut, M., Ohayon, J., Gupta, S., Bomboi, G., Gaindh, D., Cantor, F. K., Frank, J. A., McFarland, H. F., Bagnato, F. Mon, 10 Nov 2008 00:00:00 -0000
Objectives To investigate the heterogeneity in magnetic resonance image (MRI) patterns of response to interferon beta across patients with multiple sclerosis or within an individual patient over time.Design, Setting, and Patients Fifteen patients with relapsing-remitting multiple sclerosis underwent monthly MRIs and clinical examinations (6-month pretherapy phase and 36-month therapy phase) and bimonthly neutralizing antibody tests. On each MRI, the total number of contrast-enhancing lesions was noted. Therapy MRI responders were defined as those with a reduction of 60% or more in the total number of contrast-enhancing lesions during each semester of therapy.Intervention Subcutaneous administration of interferon beta-1b, 250 µg, every other day for 3 years.Main Outcome Measure Reduction in the number of contrast-enhancing lesions.Results Eight patients (53.3%) were MRI responders and 7 (46.7%) were nonresponders. Of those 7, 3 (20.0%) had only an initial optimal reduction of the total number of contrast-enhancing lesions, 2 (13.3%) never reached an optimal response, and 2 (13.3%) had a delayed optimal response. No clear association between neutralizing antibody profile and MRI response was evident.Conclusions Multiple MRI evaluations disclose that approximately only half of the patients treated with interferon beta achieve and maintain a full response to the drug over time, although an additional small number of individuals may still restore an optimal response to the drug after an initial failure.Published online November 10, 2008 (doi:10.1001/archneur.66.1.noc80047).
ABOUT THIS JOURNAL: About This Journal
Mon, 08 Dec 2008 00:00:00 -0000
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Associated Disorders: Journal focuses on Alzhiemer Disease and related disorders. Published monthly. Full-text content, online-only content available upon subscription. Published by LWW.Development: Journal devoted to publishing review articles and papers in the field of Child Neurology and related sciences. Online issues available since 1999.
Metabolism: Journal of Cerebral Blood Flow & Metabolism stands at the interface between basic and clinical neurovascular research, and features research on experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with ...
Acta Neurologica Belgica: Published by Royal Association of Belgian Medical Scientific Societies. 4 issues a year.
Acta Neurologica Scandinavica: An international forum for the dissemination of information advancing the science or practice of neurology and neurosurgery. It represents a high scientific quality of original clinical, diagnostic and experimental work in those fields.
Acta Neuropathologica: Acta Neuropathologica - Pathology. Acta Neuropathologica publishes manuscripts dealing with disease mechanisms, general, experimental, comparative, and molecular pathology of the nervous tissue. Papers on surgical neuropathology are...
Advances in Clinical Neuroscience and Rehabilitation: ACNR is a free bi-monthly magazine / journal for specialists in neurology, rehabilitation, neuroscience, and neurosurgery. It is also read by geriatricians, specialists in elderly medicine, stroke specialists and nurses with an interest in epilepsy, parkinson's disease, multiple sclerosis and alz...
African Journal of Neurological Sciences: African Journal of Neurological Sciences
American Journal of Alzheimer's Disease and Other Dementias: Prime National Publishing Corp. publishers of professional peer-reviewed healthcare journals
Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders: Official journal of the World Federation of Neurology Research Group on Motor Neuron Disease publishes clinical and experimental reasearch on motor neuron disorders. Published 4 times a year by Taylor Francis Health Sciences.
Annals of Neurology: Official journal of the American Neurological Association and the Child Neurology Society. Full-text content available upon subscription.
Aphasiology: Journal concerned with all aspects of language impairment and related disorders resulting from brain damage. It provides a forum for the exchange of knowledge and the dissemination of current research and expertise in all aspects of aphasia and related topics, from all disciplinary perspectives.
Archives of Neurology: Archives of Neurology is a monthly professional medical journal published by the American Medical Association. Archives of Neurology publishes original, peer-reviewed scientific research of the nervous system as well as the various mechanisms of disease
Autonomic Neuroscience: Journal published by International Society for Autonomic Neuroscience (ISAN) for publication and dissemination of original investigations on the autonomic nervous system. Published by Elsevier since 2000.
BMC Neurology: BioMedCentral Neurology publishes original research articles in all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology. BMC Neurology is indexed by PubMed. Full text content available online for f...
Brain: One of the eldest neurological journals. Leading studies in neurological science and practical clinical articles. Free access to editorials and abstracts.
Brain Aging: International journal published by Ana Aslan Academy of Aging attempts to explain in a clear and scientific language the latest news from all over the world related to brain aging. Fulltext contents available for free in *.pdf format.
Brain and Cognition: Journal publishes original research articles, theoretical papers, critical reviews, case histories, historical articles, and scholarly notes relevant to all aspects of human neuropsychology other than language or communication.
Brain Injury: Research journal of the International Brain Injury Association, covering all aspects of brain injury from basic science, neurological techniques and outcomes to rehabilitation and outcome.
Brain Tumor Pathology: Brain Tumor Pathology - Neurology. Brain Tumor Pathology is the official journal of the Japan Society of Brain Tumor Pathology. This international journal documents the latest research and topical debate in all clinical and experime...
BrainLINC: brainLINC(tm) is an unique and innovative approach in continuing medical education.
Cephalalgia: Cephalalgia: journal information, contents lists and abstracts on the Blackwell Publishing website.
Cerebrovascular diseases: International forum for scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with stroke and cerebrovascular diseases. Published 8 times a year.
Child's Nervous System: Official journal of the International Society for Pediatric Neurosurgery (ISPN). Covers all aspects of the pediatric neurosciences.
Clinical Autonomic Research: Steinkopff Verlag, medical publishing company, journals and Books, German Society for Biological Psychiatry index
Clinical Neurology and Neurosurgery: Papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of interest to Neurologists and Neurosurgeons world-wide. The journal complements the renowned Handbook of Clinical Neurology.
Clinical Neurophysiology: Journal of research and other information on all aspects of the field, both normal and abnormal, including human physiology and pathophysiology of both the central and the peripheral nervous system, and applications of neuroimaging and other techniques.
Clinical Neuroscience Research: Official journal of the Association for Research in Nervous and Mental Disease. The focus is on basic neuroscience and clinical investigations of cognition, mood, behavior and motor function of both normal and abnormal brain function.
Continuum: CME journal published by the American Academy of Neurology. 6 issues per year. Subscribers get ACCME accredited self-study materials that reflect key clinical and scientific developments in neurology.
Current Neurology and Neuroscience Reports: Provides the views of experts on current advances in neurology and neuroscience and selections of the most important papers. Free access to abstracts; full text requires subscription.
Current Opinion in Neurology: Website provides access to full-text content, online-only content, features and services, author submission materials and title-specific information. An LWWonline partner.
Current Treatment Options in Neurology: Provides views of experts on current treatment options in neurology and selections annotated by experts of the most interesting papers from original publications. Free access to abstracts, full text only by subscription.
Dementia and Geriatric Cognitive Disorders: Professional journal concentrating on cognitive problems caused by neurodegenerative disorders.
Developmental Medicine and Child Neurology: Covers a wide range of clinical topics concerning the neurological diseases and disabilities of children.
Developmental Medicine and Child Neurology: Official publication of British Paediatric Neurology Association is focusing on issues related to research and reviews in pediatric neurology.
Epilepsia: Epilepsia: journal information, contents lists and abstracts on the Blackwell Publishing website.
Epilepsy Currents: Epilepsy Currents: journal information, contents lists and abstracts on the Blackwell Publishing website.
Epilepsy Research: Journal focuses on experimental and clinical epileptology. Principal emphasis of the research is concerned with brain mechanisms in epilepsy.
European Journal of Neurology: European Journal of Neurology: journal information, contents lists and abstracts on the Blackwell Publishing website.
European Journal of Paediatric Neurology: The official journal of the European Paediatric Neurology Society, successor to the long-established European Federation of Child Neurology Societies. 6 issues per year plus supplements.
European Neurology: Journal covers clinical aspects of diseases of the nervous system and muscles, as well as their neuropathological, biochemical, and electrophysiological basis. Published by Karger.
European Spine Journal: European Spine Journal - Orthopedics. "European Spine Journal" is a publication founded in response to the increasing trend toward specialization in spinal surgery. The Journal is devoted to spine surgery and all related d...
Experimental Brain Research: Experimental Brain Research - Neurosciences. Experimental Brain Research was founded in 1966. Editorial Board: P. Dell, J.C. Eccles, D.M. MacKay, D. Ploog, J. Szentágothai, H. Waelsch.Experimental Brain Research publishes original c...
Experimental Neurology: Publishes the results and conclusions of original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity, and transplantation.
Functional Neurology: Provides a medium for the publication of scientific contributions dealing with all aspects of functional neurology. It focuses on the interaction of the nervous system with the environment. Includes author instructions, and subscription details.
Headache Currents: Headache Currents: Journal information, contents and abstracts on the Blackwell Publishing website.
Headache: The Journal of Head and Face Pain: Headache: The Journal of Head and Face Pain: journal information, contents lists and abstracts on the Blackwell Publishing website.
Internet Journal of Neurology: Peer reviewed journal published and archived by Internet Scientific Publications LLC and recognized by The Library of Congress Catalog of Publications. Free access to full text articles.
Journal of Alzheimer's Disease: International multidisciplinary journal to facilitate progress in understanding the etiology and pathogenesis of Alzheimer's disease and is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. Published by IOS Press.
Journal of Clinical Neurophysiology: Official journal of the American Clinical Neurophysiology Society.
Journal of Clinical Neuroscience: The official journal of Neurosurgical Society of Australasia Australian Association of Neurologists.
Journal of Headache and Pain: The Journal of Headache and Pain - Medicine. The Journal of Headache and Pain is specifically dedicated to researchers involved in all aspects of headache and pain, including theory, methodology, clinical practice and care. The Jour...
Journal of Integrative Neuroscience: The aim of the Journal is to understand the integrative mechanisms underlying brain functioning across hierarchical levels of neural organization in health and disease.
Journal of Molecular Neuroscience: Humana Press publishes scientific and medical books, journals, e-books, online journals, and CD-ROMs for the research professional and physicians. Humana publishes in the fields of biochemistry, molecular biology, oncology, cardiology, genomics, proteomics, bioinformatics, genetics, pathology, ne...
Journal of Neuro-Ophthalmology: Official publication of The North American Neuro-Ophthalmology Society.
Journal of Neurological Sciences: Official journal of the World Federation of Neurology focusing on clinical neurology and the basic sciences.
Journal of Neurology: Journal of Neurology - Neurology. The Journal of Neurology is an international journal which officially represents the European Neurological Society and provides a source for publishing original communications on clinical neurology...
Journal of Neurology, Neurosurgery, and Psychiatry: JNNP, a peer review journal for health professionals and researchers in all areas of neurology
Journal of Neurophysiology: Web site for Journal of Neurophysiology.
Journal of Neuroscience: Weekly official journal of the Society for Neuroscience.
Journal of NeuroVirology: Official journal of The International Society for NeuroVirology provides a forum for researchers and clinician scientists involved in the study of neurovirology. Published bi-monthly by Taylor and Francis Group.
Journal of Stroke and Cerebrovascular Diseases: Official publication of the National Stroke Association and The Japan Stroke Society focuses on basic and clinical science related to the fields of stroke and cerebrovascular diseases.
Journal of Stroke and Cerebrovascular Medicine: Deals with management of stroke.
Journal of the Neurological Sciences: Official Journal of the World Federation of Neurology provides the interface between clinical neurology and the basic sciences. Emphasis is placed on sound scientific developments which are or will soon become relevant to the clinician. Published by Elsevier.
Journal of Turkish Neurological Sciences: On-line peer-reviewed and quarterly published e-journal. Official publication of the Aegean Neurological Society. All abstracts (Adobe .pdf format) are in English. Full-texts are either in English or in Turkish. Free to access.
Journal Watch Neurology: Summaries and commentary of neurology medical journal articles covering topics such as Alzheimer's disease, epilepsy, multiple sclerosis.
Lancet Neurology: Neurological version of Lancet started May 2002. Many papers available for free download.
Movement Disorders: Official journal of the Movement Disorders Society.
Muscle and Nerve: Journal for EMG related research. Registration required to access.
Nature Clinical Practice Neurology: Nature Clinical Practice Neurology will deliver timely interpretations of key research developments, translating the latest findings into clinical practice. Our Editor-in-Chief and international Advisory Board will ensure comprehensive coverage of topical issues throughout the year, with the high...
Nervenarzt: Der Nervenarzt - Medicine. Der Nervenarzt versteht sich als Zeitschrift für alle Gebiete nervenärztlicher Forschung, aber auch Praxis. So wird aus Spezialfächern berichtet, die heute als Fachrichtungen eigene Publikationsb...
Neura: Designed for healthcare professionals, Neura.net includes the latest neurodegenerative research; provides reviews of timely clinical, practice, and disease issues; and offers patient materials.
Neuro-degenerative diseases: Professional publication focused on clinical and laboratory research in neurodegenerative disorders.
Neurocase: Journal of both adult and child case studies in neuropsychology, neuropsychiatry and behavioral neurology. Published by Swets and Zeitlinger (6 issues per year).
Neurogenetics: Neurogenetics - Neurosciences. "Neurogenetics" publishes findings that contribute to a better understanding of the genetic basis of normal and abnormal function of the nervous system. Neurogenetic disorders is the main foc...
NeuroImage: Focuses on publishing research on imaging and mapping strategies to study the brain's structure, function and the relationship between the two, from the whole brain to the tissue level. Abstracts available since the first issue, full-text articles require subscription.
Neurologic Clinics of North America: Journal provides comprehensive, clinical reviews of timely subjects, including diagnosis and therapy, new materials, and new equipment. Each issue contains invited reviews (usually 10-14 per issue) on a single topic in neurology and is presented under the direction of an experienced guest editor.
Neurological Research: International peer-reviewed journal publishing original and fundamental studies as well as clinical research in areas of neurology, neurosurgery and neurosciences.
Neurological Sciences: Neurological Sciences - Neurology. Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspe...
Neurologist, The: Website provides access to full-text content, online-only content, features and services, author submission materials and title-specific information. An LWWonline partner.
Neurology: Web site for Neurology.
Neurology India: Neurol India is an peer-reviewed biomedical periodical of Neurological Society of India.
NeuroMolecular Medicine: Research articles and critical reviews on the molecular and biochemical basis of neurological disorders.
Neuromuscular Disorders: Official Journal of the World Muscle Society, covers all aspects of neuromuscular disorders in childhood and adult life. Online archive covers all issues since 1997.
Neuron: Neuroscience journal published by Cell press. Abstracts since 1988 available for free. Fulltext issues available for 1996-current issues.
Neuropeptides: Original research and reviews dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems.
Neuropsychiatry, Neuropsychology, and Behavioral Neurology: Official journal of the Behavioral Neurology Society. Each quarterly issue presents original research articles on basic brain processes, critical review articles, case reports, and brief reports on preliminary studies and pertinent clinical issues.
Neuroradiology: Neuroradiology - Radiology. Neuroradiology is a discipline that covers the medical aspects of interpretation of a great variety of imaging techniques in the neurosciences as well as those aspects of treatment that are covered by the...
NeuroReport: Access to tables of contents and abstracts, instructions for authors, related web links, subscription information. Subscription is required to access full-text content.
NeuroRx: Official journal of the American Society for Experimental NeuroTherapeutics (ASENT). Published quarterly since January 2004. Each issue provides critical reviews focused on a single important topic relating to the treatment of neurological disorders.
Neuroscience BiblioAlerts: Customized scientific and technical information reports delivered immediately on a fee per paper basis.
Parkinsonism and Related Disorders: Results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Useful for all neurologists specialising in Parkinson's Disease and other mo...
Pediatric Neurology: Journal publishes peer-reviewed clinical and research articles covering all aspects of the developing nervous system, the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders.
Polish Journal of Neurology and Neurosurgery: Official Journal of Polish Neurological Society. Access to the list of past issues starting from 1990, abstracts and selected full text supplements, published since 1997.
Practical Neurology: Practical, up-to-the-minute digest of all the important developments in neurology. Published by Blackwell since 2001. Fulltext papers available on subscription.
Reviews in Neurological Diseases: Journal covering review papers and conference reports. Published 4 times a year.
Revista de NeurologÃa: Publicación quincenal destinada a publicar trabajos de neurociencias clínicas y experimentales. Fundada el 1973
Seizure: International forum for the publication of peer-reviewed papers on topics related to epilepsy.
Seminars in Neurology: Quarterly review journal that publishes issues devoted to a broad range of pivotal topics in contemporary neurology, published by Thieme.
Sinapse: Electronic journal of Portuguese Neurological Society. Open access to issues in pdf format.
Sleep Medicine: Journal primarily focusing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine. Published by Elsevier Science since 2000.
Spine: Bi-weekly peer review journal of spine surgery. Access to contents, abstracts, author, and subscription information.
Stroke: Journal on cerebrovascular diseases published by American Heart Association. Abstracts and sample issue available online. Full text available for subscription.
Surgical Neurology: Journal provides comprehensive peer-reviewed coverage of the latest developments in neurosurgery. Audience includes neurosurgeons, neuroscientists and physicians specializing in medical imaging (especially CAT scanning).
The Canadian Journal of Neurological Sciences: Canadian Journal Of Neurological Sciences: An international neurological sciences medical journal which publishes peer reviewed original articles
The Clinical Neuropsychologist: The Official Journal of The American Academy of Clinical Neuropsychology. It is designed to provide a forum for presentations and discussions for practicing clinical neuropsychologists.
World Neurology: Newsletter published by World Federation of Neurology in cooperation with Elsevier Science. Fulltext contents in *.pdf format available since October 1999 issue.
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