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Permanent Neurology Job in Morristown Tennessee with Community Health Systems
Opportunity for a Non-Invasive Cardiologist to have a Solo Practice or join two (2) other Cardiologists in Morristown, a beautiful town in upper east Tennessee only 40 minutes from Knoxville. Call coverage
Permanent Neurology Job in Florence South Carolina with Community Health Systems
Excellent opportunity to join a busy, established practice This position will be to join a local physician with a very busy practice. Compensation and benefits will be in accordance with MGMA standards,
Permanent Neurology Job in Huntsville Alabama with Community Health Systems
PRIVATE PRACTICE OPPORTUNITY IN NORTH ALABAMA Huntsville is seeking a BE/BC Neurologist to join another in private practice, to start in 2009. Call coverage to be shared with another group. Contact:
Archives of Neurology recent issues
ORIGINAL CONTRIBUTION: Heterogeneity in Response to Interferon Beta in Patients With Multiple Sclerosis: A 3-Year Monthly Imaging Study
Chiu, A. W., Richert, N., Ehrmantraut, M., Ohayon, J., Gupta, S., Bomboi, G., Gaindh, D., Cantor, F. K., Frank, J. A., McFarland, H. F., Bagnato, F. Mon, 10 Nov 2008 00:00:00 -0000
Objectives To investigate the heterogeneity in magnetic resonance image (MRI) patterns of response to interferon beta across patients with multiple sclerosis or within an individual patient over time.Design, Setting, and Patients Fifteen patients with relapsing-remitting multiple sclerosis underwent monthly MRIs and clinical examinations (6-month pretherapy phase and 36-month therapy phase) and bimonthly neutralizing antibody tests. On each MRI, the total number of contrast-enhancing lesions was noted. Therapy MRI responders were defined as those with a reduction of 60% or more in the total number of contrast-enhancing lesions during each semester of therapy.Intervention Subcutaneous administration of interferon beta-1b, 250 µg, every other day for 3 years.Main Outcome Measure Reduction in the number of contrast-enhancing lesions.Results Eight patients (53.3%) were MRI responders and 7 (46.7%) were nonresponders. Of those 7, 3 (20.0%) had only an initial optimal reduction of the total number of contrast-enhancing lesions, 2 (13.3%) never reached an optimal response, and 2 (13.3%) had a delayed optimal response. No clear association between neutralizing antibody profile and MRI response was evident.Conclusions Multiple MRI evaluations disclose that approximately only half of the patients treated with interferon beta achieve and maintain a full response to the drug over time, although an additional small number of individuals may still restore an optimal response to the drug after an initial failure.Published online November 10, 2008 (doi:10.1001/archneur.66.1.noc80047).
ORIGINAL CONTRIBUTION: Decrease in the Numbers of Dendritic Cells and CD4+ T Cells in Cerebral Perivascular Spaces Due to Natalizumab
Martin, M. d. P., Cravens, P. D., Winger, R., Frohman, E. M., Racke, M. K., Eagar, T. N., Zamvil, S. S., Weber, M. S., Hemmer, B., Karandikar, N. J., Kleinschmidt-DeMasters, B.K., Stuve, O. Mon, 13 Oct 2008 00:00:00 -0000
Objective To extend our studies on the prolonged and differential effect of natalizumab on T lymphocyte numbers in the cerebrospinal fluid, we investigated the number and phenotypes of leukocytes and the expression of major histocompatibility complex (MHC) classes I and II in cerebral perivascular spaces (CPVS). We hypothesized that natalizumab reduces the number of antigen presenting cells in CPVS.Design A case-control study in which inflammatory cell numbers in the CPVS of cerebral tissue were assessed by immunohistochemical staining.Subjects A patient with multiple sclerosis (MS) who developed progressive multifocal leukoencephalopathy (PML) during natalizumab therapy. Controls included location-matched cerebral autopsy material of patients without disease of the central nervous system, patients with MS not treated with natalizumab, and patients with PML not associated with natalizumab therapy.Results The absolute number of CPVS in the patient with MS treated with natalizumab was significantly lower than in the control groups owing to extensive destruction of the tissue architecture. The expression of MHC class II molecules and the number of CD209+ dendritic cells were significantly decreased in the CPVS of the patient with MS treated with natalizumab. No CD4+ T cells were detectable.Conclusions Our observations may explain the differential and prolonged effects of natalizumab therapy on leukocyte numbers in the cerebrospinal fluid.Published online October 13, 2008 (doi:10.1001/archneur.65.12.noc80051).
ABOUT THIS JOURNAL: About This Journal
Mon, 10 Nov 2008 00:00:00 -0000
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Permanent Neurology Job in Morristown Tennessee with Community Health Systems
Opportunity for a Non-Invasive Cardiologist to have a Solo Practice or join two (2) other Cardiologists in Morristown, a beautiful town in upper east Tennessee only 40 minutes from Knoxville. Call coverage
Permanent Neurology Job in Florence South Carolina with Community Health Systems
Excellent opportunity to join a busy, established practice This position will be to join a local physician with a very busy practice. Compensation and benefits will be in accordance with MGMA standards,
Permanent Neurology Job in Huntsville Alabama with Community Health Systems
PRIVATE PRACTICE OPPORTUNITY IN NORTH ALABAMA Huntsville is seeking a BE/BC Neurologist to join another in private practice, to start in 2009. Call coverage to be shared with another group. Contact:
Archives of Neurology recent issues
ORIGINAL CONTRIBUTION: Heterogeneity in Response to Interferon Beta in Patients With Multiple Sclerosis: A 3-Year Monthly Imaging Study
Chiu, A. W., Richert, N., Ehrmantraut, M., Ohayon, J., Gupta, S., Bomboi, G., Gaindh, D., Cantor, F. K., Frank, J. A., McFarland, H. F., Bagnato, F. Mon, 10 Nov 2008 00:00:00 -0000
Objectives To investigate the heterogeneity in magnetic resonance image (MRI) patterns of response to interferon beta across patients with multiple sclerosis or within an individual patient over time.Design, Setting, and Patients Fifteen patients with relapsing-remitting multiple sclerosis underwent monthly MRIs and clinical examinations (6-month pretherapy phase and 36-month therapy phase) and bimonthly neutralizing antibody tests. On each MRI, the total number of contrast-enhancing lesions was noted. Therapy MRI responders were defined as those with a reduction of 60% or more in the total number of contrast-enhancing lesions during each semester of therapy.Intervention Subcutaneous administration of interferon beta-1b, 250 µg, every other day for 3 years.Main Outcome Measure Reduction in the number of contrast-enhancing lesions.Results Eight patients (53.3%) were MRI responders and 7 (46.7%) were nonresponders. Of those 7, 3 (20.0%) had only an initial optimal reduction of the total number of contrast-enhancing lesions, 2 (13.3%) never reached an optimal response, and 2 (13.3%) had a delayed optimal response. No clear association between neutralizing antibody profile and MRI response was evident.Conclusions Multiple MRI evaluations disclose that approximately only half of the patients treated with interferon beta achieve and maintain a full response to the drug over time, although an additional small number of individuals may still restore an optimal response to the drug after an initial failure.Published online November 10, 2008 (doi:10.1001/archneur.66.1.noc80047).
ORIGINAL CONTRIBUTION: Decrease in the Numbers of Dendritic Cells and CD4+ T Cells in Cerebral Perivascular Spaces Due to Natalizumab
Martin, M. d. P., Cravens, P. D., Winger, R., Frohman, E. M., Racke, M. K., Eagar, T. N., Zamvil, S. S., Weber, M. S., Hemmer, B., Karandikar, N. J., Kleinschmidt-DeMasters, B.K., Stuve, O. Mon, 13 Oct 2008 00:00:00 -0000
Objective To extend our studies on the prolonged and differential effect of natalizumab on T lymphocyte numbers in the cerebrospinal fluid, we investigated the number and phenotypes of leukocytes and the expression of major histocompatibility complex (MHC) classes I and II in cerebral perivascular spaces (CPVS). We hypothesized that natalizumab reduces the number of antigen presenting cells in CPVS.Design A case-control study in which inflammatory cell numbers in the CPVS of cerebral tissue were assessed by immunohistochemical staining.Subjects A patient with multiple sclerosis (MS) who developed progressive multifocal leukoencephalopathy (PML) during natalizumab therapy. Controls included location-matched cerebral autopsy material of patients without disease of the central nervous system, patients with MS not treated with natalizumab, and patients with PML not associated with natalizumab therapy.Results The absolute number of CPVS in the patient with MS treated with natalizumab was significantly lower than in the control groups owing to extensive destruction of the tissue architecture. The expression of MHC class II molecules and the number of CD209+ dendritic cells were significantly decreased in the CPVS of the patient with MS treated with natalizumab. No CD4+ T cells were detectable.Conclusions Our observations may explain the differential and prolonged effects of natalizumab therapy on leukocyte numbers in the cerebrospinal fluid.Published online October 13, 2008 (doi:10.1001/archneur.65.12.noc80051).
ABOUT THIS JOURNAL: About This Journal
Mon, 10 Nov 2008 00:00:00 -0000
Sites:
Family Practice Notebook: Neurology: Covers Autonomic, Cerebellum, Chorea, Cranial Nerve, Cognitive, CSF, Demyelinating, Disability, Examination, Headache, Level of Consciousness, Motor, Procedure, Seizure, Sensory, Symptom Evaluation and Tremor. Related chapters from other specialties include Cardiovascular, Dermatology, Ophthalmo...Foundation for Education and Research in Neurological Emergencies: Information about this non-profit organization for improving the care of Emergency Department patients with neurological emergencies. Offers free educational courses and sponsors research for Emergency Physicians.
General Practice Notebook - Neurology: Coverage of this medical specialty.
HowStuffWorks: How Your Brain Works: Every animal you can think of -- mammals, birds, reptiles, fish, amphibians -- all have brains. But the human brain is unique. It gives us the power to think, plan, speak, imagine... Find out all about this amazing organ.
Institute for Nerve Medicine: Presenting information on disorders of the cranial, spinal and peripheral nerves. Includes illustrated descriptions of treatment options.
Iowa Neuroradiology Library: Department of Neurology, University of Iowa Hospitals and Clinics. Radiology teaching file.
National Institute of Neurological Disorders and Stroke: An NIH site with research and clinical information on disorders of the brain and nervous system.
Neuroconsult: Information resource on Clinical Neurology. Covering areas such as alzheimers, epilepsy, migraine, motor neurone, multiple sclerosis, pain, parkinsons, schizophrenia, and stroke.
NeuroExam.com: neuroexam.com is an interactive online guide to the neurologic examination, with video demonstrations. It is a companion to 'The NeuroExam Video' and 'Neuroanatomy Through Clinical Cases', both by Hal Blumenfeld
Neurological Teaching Videos: Digital video of the neurologic exam [Online registration, (free) required] by Wright State University.
Neurology Channel: NeurologyChannel is a comprehensive resource for seizures, stroke, coma, Alzheimer's, headaches, migraines, Parkinson's, and other brain and nervous system disorders. Features patient forum and neurologist search.
Neurology in Clinical Practice, 3e: An online professional neurology reference.
Neurology Jobs: Physician employment opportunities for all specialties in North America.
Neurology-Info.net: Information about the nervous system in health and disease. Part of the ALtruis Biomedical Network.
NeurologyLinx: Neurologist keep current with free medical news and daily newsletters. NeurologyLinx and MDLinx aggregates the most current medical journal news and research from premier medical and healthcare journals and news sources. Comprehensive, specialized content updated every day on the web and in email...
Neurosciences on the Internet: Neurosciences on the Internet contains a searchable and browsable index of neuroscience resources available on the World Wide Web and other parts of the Internet. Neurobiology, neurology, neurosurgery, psychiatry, psychology, cognitive science sites and information on human neurological diseases...
Oregon Nerve Center: The Oregon Nerve Center is a leading center for research in the field of neurology.
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