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Current Opinion in Hematology - Current Table Of Contents

Editorial introductions.
Page: viiDOI: 10.1097/MOH.0b013e32831cc13d

Hematological Oncology

Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma
Sabine Schreck, Daniela Friebel, Maike Buettner, Luitpold Distel, Gerhard Grabenbauer, Lawrence S. Young, Gerald Niedobitek Wed, 15 Oct 2008 03:59:00 -0000
Classical Hodgkin Lymphoma (cHL) is morphologically characterized by a small number of tumour cells, Hodgkin and Reed-Sternberg (HRS) cells, surrounded by numerous tumour-infiltrating lymphocytes (TIL). The functional role of these TIL is still controversial. While generally considered to represent an anti-tumour immune response, TIL in cHL might result from the profoundly deregulated immunity of cHL patients. Eighty-seven cases of cHL were available to evaluate the prognostical significance of tumour-infiltrating cytotoxic T lymphocytes (CTL), T helper 1 (Th1) cells, T helper 2 (Th2) cells and regulatory T cells (Treg). We confirm that in cHL the microenvironment is dominated by Th2 cells and Treg and show that large numbers of Th2 cells are associated with significantly improved disease-free survival (p = 0.021) and event-free survival (p = 0.012). Furthermore, a high ratio of Treg over Th2 cells resulted in a significantly shortened disease-free survival (p = 0.025). These observations suggest that Treg may exert inhibitory effects on anti-tumour immune responses mediated through Th2 cells and that Th2 cells may be more important for effective anti-tumour immunity than anticipated. Copyright © 2008 John Wiley & Sons, Ltd.

Annals of Hematology

Clinical and serological characterization of autoimmune hemolytic anemia in a tertiary care hospital in North India
Fri, 02 Jan 2009 06:30:47 -0000
Abstract  Clinical and serological characterization of autoimmune hemolytic anemia (AIHA) helps in the diagnosis, management, and monitoring course of disease. In the present study, we serologically characterized the red-cell-bound autoantibodies in diagnosed AIHA patients with regards to antibody class, subclass, direct antiglobulin test (DAT) strength, and their correlation with in vivo hemolysis. A total of 157 samples were evaluated for DAT. Clinically and serologically, 43 of them were diagnosed as AIHA. Detailed serological characterization of autoantibodies was performed in these 43 patients using the gel technology. Hematological and biochemical parameters were obtained from the Hospital Information System. Polyspecific (immunoglobulin G (IgG) + C3) DAT-positive samples were tested for monospecific DAT (IgG, IgM, IgA, C3c, and C3d) and IgG subclass (IgG1 and IgG3). Thermal amplitude of autoantibodies was determined on eluates. Median age of the patients was 31 years (range, 12–70 years) with male to female ratio of 1:3.3. In 55.8% of patients, AIHA was secondary to an underlying disorder. Patients with strong reactive DAT had increased likelihood of hemolysis (p = 0.000). IgG was the solitary autoantibody coating the red cells in 72.1% of patients. Red cells coated with multiple immunoglobulins/complements and IgG subclass IgG1 and/or IgG3 were more susceptible to undergo hemolysis. Gel technology helps the immunohematologist to diagnose and serologically characterize AIHA patient with regard to red-cell-bound autoantibodies’ class, subclass, and titer as these correlate with in vivo hemolysis. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-008-0674-6Authors Sudipta Sekhar Das, Sanjay Gandhi Postgraduate Institute of Medical Sciences Department of Transfusion Medicine Lucknow IndiaSoniya Nityanand, Sanjay Gandhi Postgraduate Institute of Medical Science Department of Clinical Hematology Lucknow IndiaRajendra Chaudhary, Sanjay Gandhi Postgraduate Institute of Medical Sciences Department of Transfusion Medicine Lucknow India Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555

American Journal of Hematology

Urinary cysteinyl leukotriene E4 is associated with increased risk for pain and acute chest syndrome in adults with sickle cell disease
Joshua J. Field, James Krings, Nicole L. White, Yan Yan, Morey A. Blinder, Robert C. Strunk, Michael R. DeBaun Tue, 02 Dec 2008 13:25:00 -0000
Leukotriene E4 (LTE4) levels are associated with rate of pain episodes in children with sickle cell disease (SCD). Because complications of SCD manifest differently in adults than children, we examined a cohort of adults with SCD to determine the relationship between baseline LTE4 and SCD-related morbidity. Baseline LTE4 levels were associated with increased rates of pain and acute chest syndrome (ACS) episodes, when those with LTE4 values in the highest tertile were compared with those in the lowest tertile (pain: risk ratio 7.1, 95% CI 1.8-27.5, P = 0.005; ACS: risk ratio 12.2, 95% CI 2.1-69.8, P = 0.005). Am. J. Hematol., 2009. © 2009 Wiley-Liss, Inc.

Pediatric Hematology and Oncology: Articles recently published in

SAFETY OF HEMATOPOIETIC STEM CELL TRANSPLANTATION IN CHILDREN LESS THAN THREE YEARS OF AGE
Matthews, Edward W.Kristovich, Karen M.Wong, Wendy B.Wright, Nicola BobeyDvorak, Christopher C.Agarwal, RajniAmylon, Michael D.Weinberg, Kenneth I. Sat, 01 Nov 2008 00:00:00 -0000


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