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Permanent Gastroenterology Job in Columbus Georgia with St. Francis Hospital
St. Francis is assisting a local practice in recruiting a new partner to their practice to meet the community demand and need. This practice is a well-established multi-specialty group with 15 providers.
Permanent Gastroenterology Job in Hazard Kentucky with Appalachian Regional Healthcare
Hazard ARH Hospital BC/BE Gastroenterologist Hazard ARH Regional Medical Center is seeking a BC/BE Gastroenterologist to join its medical staff. Our 308-bed regional medical center prides itself with
Permanent Gastroenterology Job in Williamson Kentucky with Appalachian Regional Healthcare
Williamson ARH Hospital BC/BE Gastroenterologist Williamson ARH Hospital is seeking a BC/BE Gastroenterologist to join its medical staff. Our 163-bed community hospital prides itself with a high

Journal of Clinical Gastroenterology - Current Table Of Contents

Biography of Dr. Khursheed N. Jeejeebhoy.
Page: 1DOI: 10.1097/MCG.0b013e31818a8482Authors: Lewis, Myron MD, FACP, MACG
First-degree Relatives of Celiac Patients: Are They at an Increased Risk of Developing Celiac Disease?
Page: 3DOI: 10.1097/MCG.0b013e31818ca609Authors: Biagi, Federico MD; Corazza, Gino R. MD
Gastrointestinal Bleeding in the Setting of Anticoagulation and Antiplatelet Therapy.
Page: 5DOI: 10.1097/MCG.0b013e31811edd13Authors: Barada, Kassem MD *; Abdul-Baki, Heitham MD *; El Hajj, Ihab I. MD *; Hashash, Jana G. MD *; Green, Peter H. MD +

FeedNavigator - Journals - Gastroenterology

Anti-apoptotic Effect of c-Jun N-terminal Kinase-1 through Mcl-1 Stabilization in TNF-induced Hepatocyte Apoptosis
Gastroenterology / Terkko Wed, 07 Jan 2009 08:02:38 +0200

Reactive nitrogen species upregulate TNF<alpha> and matrix metalloproteinases and protect against liver fibrogenesis
Gastroenterology / Terkko Wed, 07 Jan 2009 08:02:38 +0200

Incidence of hepatocellular carcinoma in hepatitis C carriers with normal alanine aminotransferase levels?
Journal of Hepatology / Terkko Wed, 07 Jan 2009 08:02:38 +0200

A Retrospective Single-Center Review of Primary Sclerosing Cholangitis in Children.
Clinical Gastroenterology and Hepatology / Terkko Tue, 06 Jan 2009 16:09:09 +0200

Evidence of Endothelial Dysfunction in Patients With Inflammatory Bowel Disease.
Clinical Gastroenterology and Hepatology / Terkko Tue, 06 Jan 2009 16:09:09 +0200

Clinical Factors Associated With Liver Stiffness in Hepatitis B e Antigen-Positive Chronic Hepatitis B Patients.
Clinical Gastroenterology and Hepatology / Terkko Tue, 06 Jan 2009 16:09:09 +0200


PubMed: 1542-3565

A Retrospective Single-Center Review of Primary Sclerosing Cholangitis in Children.
Miloh T, Arnon R, Shneider B, Suchy F, Kerkar N Related Articles A Retrospective Single-Center Review of Primary Sclerosing Cholangitis in Children. Clin Gastroenterol Hepatol. 2008 Oct 30; Authors: Miloh T, Arnon R, Shneider B, Suchy F, Kerkar N BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and progressive bile duct fibrosis. There are limited data on pediatric PSC. METHODS: We performed a retrospective chart review of 47 pediatric patients with PSC. RESULTS: The mean age at diagnosis was 11 +/- 4.9 years. Symptoms occurred before presentation in 81% of patients; inflammatory bowel disease was found in 59% and autoimmune hepatitis (overlap syndrome) in 25% of patients. Magnetic resonance cholangiography revealed both extrahepatic and intrahepatic, isolated intrahepatic, isolated extrahepatic, and no biliary involvement (small-duct PSC) in 40%, 14%, 10%, and 36%, respectively. Advanced fibrosis (stage > II) was present in 65%. Colonoscopy revealed pancolitis, rectal sparing, and normal findings in 24%, 24%, and 18%, respectively. All patients were treated with ursodeoxycholic acid (UDCA); 9 with overlap syndrome also received immunosuppressants. Fifteen patients without overlap syndrome had positive autoimmune markers and responded to UDCA monotherapy. Liver transplantation was performed in 9 patients (3 with overlap syndrome and 2 with small-duct PSC) at a median time of 7 years after diagnosis. The 10-year posttransplant survival rate was 89%. CONCLUSIONS: In one of the largest single-center studies of children with PSC, we found that most children with PSC had inflammatory bowel disease or autoimmune overlap and advanced fibrosis at diagnosis. Levels of alanine aminotransferase and gamma-glutamyl transferase were highest in patients with overlap syndrome and lowest in those with small-duct PSC. Levels of serum liver enzymes normalized after therapy with UDCA, including patients with positive autoimmune markers without histologic features of autoimmune hepatitis. PMID: 19121649 [PubMed - as supplied by publisher]
Evidence of Endothelial Dysfunction in Patients With Inflammatory Bowel Disease.
Roifman I, Sun YC, Fedwick JP, Panaccione R, Buret AG, Liu H, Rostom A, Anderson TJ, Beck PL Related Articles Evidence of Endothelial Dysfunction in Patients With Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2008 Oct 30; Authors: Roifman I, Sun YC, Fedwick JP, Panaccione R, Buret AG, Liu H, Rostom A, Anderson TJ, Beck PL BACKGROUND & AIMS: Chronic inflammation has a major role in the development and propagation of endothelial dysfunction, which can lead to coronary artery disease. Endothelial dysfunction has been described in patients with various and diverse chronic inflammatory conditions. Altered vascular flow has been proposed to mediate inflammation in inflammatory bowel disease (IBD), although the role of endothelial dysfunction remains obscure. The purpose of our study was to assess endothelial function in patient with IBD. METHODS: Ninety-eight subjects were included in this study; 48 with IBD (17 with ulcerative colitis and 31 with Crohn's disease) and 50 healthy controls. Endothelial function was assessed by pulse arterial tonometry (PAT) and brachial ultrasound to determine flow-mediated dilation and shear stress reactive hyperemia. The impact of disease activity, disease duration, and IBD therapy also was assessed. RESULTS: Baseline demographic characteristics, including cardiovascular risk factors, were similar in all groups. IBD patients showed microvascular endothelial dysfunction, with lower PAT indices (P < .01) and shear stress reactive hyperemia (P < .05) compared with controls. There was no relationship between microvascular endothelial dysfunction, disease duration, underlying therapy, or clinical disease activity. There was a positive association between lower PAT scores and recent abdominal pain (P < .05). CONCLUSIONS: This was a large study assessing endothelial dysfunction in IBD. Both ulcerative colitis and Crohn's disease patients showed evidence of microvascular endothelial dysfunction. Future research could determine whether endothelial dysfunction is involved in the pathogenesis of IBD or increases the risk of cardiovascular events in this patient population. PMID: 19121648 [PubMed - as supplied by publisher]
Clinical Factors Associated With Liver Stiffness in Hepatitis B e Antigen-Positive Chronic Hepatitis B Patients.
Wong GL, Wong VW, Choi PC, Chan AW, Chim AM, Yiu KK, Chan HY, Chan FK, Sung JJ, Chan HL Related Articles Clinical Factors Associated With Liver Stiffness in Hepatitis B e Antigen-Positive Chronic Hepatitis B Patients. Clin Gastroenterol Hepatol. 2008 Oct 30; Authors: Wong GL, Wong VW, Choi PC, Chan AW, Chim AM, Yiu KK, Chan HY, Chan FK, Sung JJ, Chan HL BACKGROUND & AIMS: We analyzed the clinical factors associated with advanced liver fibrosis in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients. METHODS: We prospectively recruited treatment-naive HBeAg-positive patients for liver stiffness measurement (LSM) by transient elastography. Insignificant and advanced fibrosis was defined as a LSM of 6.0 kPa or less, and greater than 9.0 kPa for patients with alanine aminotransferase (ALT) levels less than or equal to the f upper limit of normal (ULN), and 7.5 kPa or less and greater than 9.0 kPa for those with ALT levels between 1 and 5 x ULN, respectively, based on a previous study with histologic validation. RESULTS: A total of 453 patients were studied. Among 74 patients who also had a liver biopsy, the cut-off levels for advanced fibrosis had 95% specificity. Age and ALT level, but not hepatitis B virus DNA level, were associated independently with LSM. Based on receiver operating characteristics curve analysis, patients older than 35 years had the highest specificity for advanced fibrosis. The risk of advanced fibrosis increased in patients with an ALT level greater than 0.5 x ULN. Among the 47 patients who were older than 35 years with an ALT level of 0.5 x ULN or less, 39 (83%) had a LSM suggestive of insignificant fibrosis, and 1 (2%) had advanced fibrosis. Among the 217 patients who were older than 35 years with an ALT level greater than 0.5 x ULN, 61 (28%) had LSM indicating insignificant fibrosis, and 80 (37%) had advanced fibrosis. CONCLUSIONS: Risk of advanced liver fibrosis increased in HBeAg-positive patients older than 35 years of age with an ALT level greater than 0.5 x ULN. PMID: 19121647 [PubMed - as supplied by publisher]

Current Opinion in Gastroenterology - Current Table Of Contents

Editorial introductions.
Page: viiDOI: 10.1097/MOG.0b013e32831f1eef
Enteric infections and diagnostic testing.
Page: 1DOI: 10.1097/MOG.0b013e32831ba094Authors: Bennett, William E Jr; Tarr, Phillip I
Enteroaggregative Escherichia coli infection.
Page: 8DOI: 10.1097/MOG.0b013e32831dac5eAuthors: Flores, Jose; Okhuysen, Pablo C

European Journal of Gastroenterology & Hepatology - Current Table Of Contents

Ulcerative colitis: current medical therapy and strategies for improving medication adherence.
Page: 1DOI: 10.1097/MEG.0b013e32830bfb88Authors: Zhang, Zunwu; Kennedy, Hugh
Medical management of patients with ileal pouch anal anastomosis after restorative procto-colectomy.
Page: 9DOI: 10.1097/MEG.0b013e328306078cAuthors: Johnson, Matthew W. a; Das, Partha a; Dewar, David H. b; Forbes, Alastair c; Ciclitira, Paul J. b; Nicholls, Richard J. d
The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption.
Page: 18DOI: 10.1097/MEG.0b013e32830a4f4cAuthors: Imbert-Bismut, Francoise a; Naveau, Sylvie d; Morra, Rachel b; Munteanu, Mona c; Ratziu, Vlad b; Abella, Annie e; Messous, Djamila a; Thabut, Dominique b; Benhamou, Yves b; Poynard, Thierry b

Evidence-Based Gastroenterology - Current Table Of Contents

Letter From the Editor.
Page: 59DOI: 10.1097/EBG.0b013e31818e1d57Authors: Eisen, Glenn MD, MPH
RECOMBINANT FACTOR VIIA-IS IT SAFE OR EFFECTIVE FOR VARICEAL BLEEDING IN CIRRHOSIS?
Page: 60DOI: 10.1097/EBG.0b013e31818d66e0Authors: Shah, Neeral MD; Caldwell, Stephen MD
SHOULD WE USE ENDOSCOPIC OR BETA-BLOCKER THERAPY FOR PREVENTION OF FIRST VARICEAL HEMORRHAGE?
Page: 62DOI: 10.1097/EBG.0b013e31818d40efAuthors: Zaman, Atif MD, MPH

Nature Clinical Practice Gastroenterology & Hepatology

Sitting on the fence
Stephen B Hanauer Sitting on the fence Nature Clinical Practice Gastroenterology & Hepatology 5, 655 (2008). doi:10.1038/ncpgasthep1302 Author: Stephen B Hanauer
A triple-antigen Helicobacter pylori vaccine is safe and immunogenic
A triple-antigen Helicobacter pylori vaccine is safe and immunogenic Nature Clinical Practice Gastroenterology & Hepatology 5, 656 (2008). doi:10.1038/ncpgasthep1287
Prevalence and underdiagnosis of celiac disease in the elderly
Prevalence and underdiagnosis of celiac disease in the elderly Nature Clinical Practice Gastroenterology & Hepatology 5, 656 (2008). doi:10.1038/ncpgasthep1288

Inflammatory Bowel Diseases

Human neutrophil peptides 1-3 are useful biomarkers in patients with active ulcerative colitis
Shuji Kanmura, Hirofumi Uto, Masatsugu Numata, Shinichi Hashimoto, Akihiro Moriuchi, Hiroshi Fujita, Makoto Oketani, Akio Ido, Mayumi Kodama, Hidehisa Ohi, Hirohito Tsubouchi Tue, 23 Dec 2008 09:13:00 -0000
Background: A specific useful biomarker for diagnosing ulcerative colitis (UC) has not yet been described. This study employed proteomics to identify serum protein biomarkers for UC.Methods: Ninety-four blood samples were isolated from patients and controls (including 48 UC, 22 Crohn's disease [CD], 5 colorectal cancer, and 6 infectious colitis patients and 13 healthy subjects). Serum samples were analyzed using the SELDI-TOF/MS ProteinChip system. After applying the samples to ProteinChip arrays, we assessed differences in the proteomes using Ciphergen ProteinChip software and identified candidate proteins, which were then characterized in immunoassays.Results: Preliminary analysis using the ProteinChip system revealed significant peak-intensity differences for 27 serum proteins between 11 patients with UC and 7 healthy subjects. Among these proteins, 3 proteins (with mass/charge ratios of approximately 3400) were identified as human neutrophil peptides 1-3 (HNP 1-3). The presence of HNP 1-3 in the patient sera was confirmed using immunoassays. Enzyme-linked immunosorbent assays demonstrated that the mean plasma concentration of HNP 1-3 was significantly higher in patients with active UC (n = 28) than in patients whose UC was in remission (n = 20) or patients with CD (n = 22), infectious colitis, or healthy subjects, and tended to be higher than in patients with colon cancer. In addition, the plasma concentration of HNP 1-3 in patients that responded to corticosteroids-based therapy decreased after treatment, whereas it was not changed in nonresponders.Conclusions: HNP 1-3 is a novel biomarker that may be useful for diagnosing patients with active UC and predicting treatment outcomes.(Inflamm Bowel Dis 2008)
Patients' attitudes to medicines and adherence to maintenance treatment in inflammatory bowel disease
Rob Horne, Rhian Parham, Richard Driscoll, Andrew Robinson Tue, 23 Dec 2008 09:13:00 -0000
Background: Nonadherence has been reported in over 40% of patients taking maintenance therapies (MT) for inflammatory bowel disease (IBD). Studies in other illness groups have shown that nonadherence is related to negative attitudes to treatment. The aim of this study was to assess patients' attitudes to MT for IBD (beliefs about personal need for MT and potential adverse effects) and to identify whether such beliefs are associated with adherence to MT.Methods: A cross-sectional survey was conducted in which 1871 members of the National Association for Colitis and Crohn's Disease (NACC) completed validated questionnaires assessing beliefs about MT and adherence to MT.Results: Low adherence to MT was reported by 29% of participants and was associated with doubts about personal need for MT (odds ratio [OR] = 0.56; 95% confidence interval [CI]: 0.48-0.64; P < 0.001) and concerns about potential adverse effects (OR = 1.66; 95% CI: 1.42-1.94; P < 0.001). Attitudinal analysis showed that while almost half (48%) of the participants were "accepting" of MT (high necessity, low concerns), a large proportion of the sample (42%) were "ambivalent" about MT (high necessity, high concerns), 6% were "sceptical" (low necessity, high concerns) and 4% were "indifferent" (low necessity, low concerns). Compared to those who were "accepting" of MT, participants in all 3 other attitudinal groups were significantly more likely to be nonadherent.Conclusions: The way in which patients judge their personal need for MT relative to their concerns about MT can be a significant barrier to adherence. Interventions to facilitate optimal adherence to MT for IBD should address such perceptual barriers.(Inflamm Bowel Dis 2008)
Is chronic pain an extraintestinal manifestation of IBD?
Corey A. Siegel, Richard P. MacDermott Tue, 23 Dec 2008 09:13:00 -0000
No abstract.

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