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Permanent Gastroenterology Job in Valparaiso Indiana with Community Health Systems
Digestive Health Care Associates is searching for an additional physician to join their group of 3 in a well established practice of 31 years in the community of Valparaiso, Indiana. They practice in
Permanent Gastroenterology Job in Fort Wayne Indiana with Community Health Systems
Hospital employed group with one other This opportunity is hospital employed with one other gastroenterologist in Fort Wayne, Indiana. A strong and competitive financial package will be offered that
Permanent Gastroenterology Job in West Grove Pennsylvania with Community Health Systems
Jennersville Regional is searching for a gastroenterologist to begin a solo practice. This is an excellent region, located in Chester County, and less than 1 hour west of Philadelphia. Strong medical

Journal of Clinical Gastroenterology - Current Table Of Contents

The Lactulose Breath Test (LBT): Modified, But Still a Lot of Hot Air?
Page: 1067DOI: 10.1097/MCG.0b013e31818474edAuthors: Lieb, John G. MD; Draganov, Peter V. MD
Gastroenterologists' Patient Instructions for Oral Sodium Phosphate Solution for Colonoscopy Preparation: A Survey Among Gastroenterologists in the State of Indiana.
Page: 1070DOI: 10.1097/MCG.0b013e3180f62b25Authors: Gagovic, Veronika MD; Rex, Douglas K. MD
Prevalence and Clinical Characteristics of Barrett's Esophagus in a Chinese General Population.
Page: 1074DOI: 10.1097/MCG.0b013e31809e7126Authors: Tseng, Ping-Huei MD *; Lee, Yi-Chia MD + ++; Chiu, Han-Mo MD ++; Huang, Shih-Pei MD ++; Liao, Wei-Chih MD ++; Chen, Chien-Chuan MD ++; Wang, Hsiu-Po MD [S]; Wu, Ming-Shiang MD, PhD ++; Lin, Jaw-Town MD, PhD ++

FeedNavigator - Journals - Gastroenterology

Clinical and biological significance of angiogenesis and lymphangiogenesis in colorectal cancer.
Digestive and Liver Disease / Terkko Sat, 29 Nov 2008 16:01:04 +0200

Pancreatic Cancer
Gastroenterology / Terkko Sat, 29 Nov 2008 08:25:30 +0200

Colon Cancer Screening, Surveillance, Prevention and Therapy. Mitchell S. Cappell, guest editor. 305 pp. $99.00. Saunders (Elsevier), Philadelphia. ISBN 9-7814-1605-8397. Web site for ordering: www.elsevier.com.
Gastroenterology / Terkko Sat, 29 Nov 2008 08:25:30 +0200

Radioembolization with 90Y Microspheres. Jose Bilbao and Maxilmillain Reiser, editors. 163 pp. $99.00. New York, New York, Springer. ISBN 9-7835-4035-4215. Web site for ordering: www.springer.com.
Gastroenterology / Terkko Sat, 29 Nov 2008 08:25:30 +0200

Hepatitis C and Hepatocellular Carcinoma: Grist for the Mill
Gastroenterology / Terkko Sat, 29 Nov 2008 08:25:30 +0200

Loss of the Ras Regulator RASAL1: Another Route to Ras Activation in Colorectal Cancer
Gastroenterology / Terkko Sat, 29 Nov 2008 08:25:30 +0200


PubMed: 1542-3565

Endoscopic Submucosal Dissection of Early Cancers, Flat Adenomas, and Submucosal Tumors in the Gastrointestinal Tract.
Probst A, Golger D, Arnholdt H, Messmann H Related Articles Endoscopic Submucosal Dissection of Early Cancers, Flat Adenomas, and Submucosal Tumors in the Gastrointestinal Tract. Clin Gastroenterol Hepatol. 2008 Sep 20; Authors: Probst A, Golger D, Arnholdt H, Messmann H BACKGROUND & AIMS: Endoscopic submucosal dissection (ESD) is a promising technique in the treatment of large premalignant and early malignant gastrointestinal lesions. In contrast to Japan and Asian countries, few data are available from Western countries. The objective of this study was to assess the feasibility of ESD in a European center, with special regard for the success rate and learning curve. METHODS: Over a 4-year-period, 82 epithelial or submucosal lesions were referred for ESD. Seventy-one ESDs were performed (51 gastric, 17 rectal, 2 esophageal, and 1 duodenal). Resection rates, procedure times, specimen sizes, complications, and recurrences were noted. The mean follow-up period was 15 months. RESULTS: Specimen size increased significantly (P < .05) and procedural duration decreased significantly (P < .005) over time. En bloc resection rates and R0 en bloc resection rates were 77.1% and 65.7%, respectively, in the first half of the study and increased to 86.1% and 72.2%, respectively, in the second half (P = NS). No recurrence was observed after R0 en bloc resection whereas the recurrence rate was 38.5% after piecemeal resections (P < .001). Two perforations in the first series were treated by surgery; 2 other perforations, 8 minor bleedings, and 2 pyloric stenoses were treated endoscopically. CONCLUSIONS: ESD is technically feasible and shows promising results in this German single-center-study. ESD is time consuming and difficult but shows a learning curve resulting in a decrease of the procedural duration over time. R0 en bloc resection is mostly possible avoiding the risk of local recurrence. PMID: 19032991 [PubMed - as supplied by publisher]

Current Opinion in Gastroenterology - Current Table Of Contents

Editorial introductions.
Page: viiiDOI: 10.1097/MOG.0b013e328316c184
Stomach and duodenum.
Page: 657DOI: 10.1097/MOG.0b013e328314b6a1Authors: Schubert, Mitchell L
Gastric secretion.
Page: 659DOI: 10.1097/MOG.0b013e328311a65fAuthors: Schubert, Mitchell L

European Journal of Gastroenterology & Hepatology - Current Table Of Contents

Oesophageal bolus transit and clearance by secondary peristalsis in normal individuals.
Page: 1129DOI: 10.1097/MEG.0b013e328303bff1Authors: Chen, Chien-Lin a b; Szczesniak, Michal M. a; Cook, Ian J. a
Prevalence of pathological duodenogastric reflux and the relationship between duodenogastric and duodenogastrooesophageal reflux in chronic gastrooesophageal reflux disease.
Page: 1136DOI: 10.1097/MEG.0b013e32830aba6dAuthors: Brillantino, Antonio; Monaco, Luigi; Schettino, Michele; Torelli, Francesco; Izzo, Giuseppe; Cosenza, Angelo; Marano, Luigi; Di Martino, Natale
Helicobacter pylori infection upregulates interleukin-18 production from gastric epithelial cells.
Page: 1144DOI: 10.1097/MEG.0b013e32830edb15Authors: Shimada, Masaaki a b; Ando, Takafumi a; Peek, Richard M. d; Watanabe, Osamu a; Ishiguro, Kazuhiro a; Maeda, Osamu a; Ishikawa, Daisuke a; Hasegawa, Motofusa a; Ina, Kenji c; Ohmiya, Naoki a; Niwa, Yasumasa a; Goto, Hidemi a

Evidence-Based Gastroenterology - Current Table Of Contents

Letter From the Editor.
Page: 59DOI: 10.1097/EBG.0b013e31818e1d57Authors: Eisen, Glenn MD, MPH
RECOMBINANT FACTOR VIIA-IS IT SAFE OR EFFECTIVE FOR VARICEAL BLEEDING IN CIRRHOSIS?
Page: 60DOI: 10.1097/EBG.0b013e31818d66e0Authors: Shah, Neeral MD; Caldwell, Stephen MD
SHOULD WE USE ENDOSCOPIC OR BETA-BLOCKER THERAPY FOR PREVENTION OF FIRST VARICEAL HEMORRHAGE?
Page: 62DOI: 10.1097/EBG.0b013e31818d40efAuthors: Zaman, Atif MD, MPH

Nature Clinical Practice Gastroenterology & Hepatology

Sitting on the fence
Stephen B Hanauer Sitting on the fence Nature Clinical Practice Gastroenterology & Hepatology 5, 655 (2008). doi:10.1038/ncpgasthep1302 Author: Stephen B Hanauer
A triple-antigen Helicobacter pylori vaccine is safe and immunogenic
A triple-antigen Helicobacter pylori vaccine is safe and immunogenic Nature Clinical Practice Gastroenterology & Hepatology 5, 656 (2008). doi:10.1038/ncpgasthep1287
Prevalence and underdiagnosis of celiac disease in the elderly
Prevalence and underdiagnosis of celiac disease in the elderly Nature Clinical Practice Gastroenterology & Hepatology 5, 656 (2008). doi:10.1038/ncpgasthep1288

Inflammatory Bowel Diseases

Alterations in myeloid dendritic cell innate immune responses in the G[alpha]i2-deficient mouse model of colitis
J.A. Peña, L. Thompson-Snipes, P.R. Calkins, N. Tatevian, M. Puppi, M.J. Finegold Tue, 25 Nov 2008 13:58:00 -0000
Background: The G protein alpha subunit type-2 (G[alpha]i2)-deficient mouse develops inflammatory bowel disease (IBD) with increased severity in mice on a 129SvEv (129) background compared to the C57BL/6 (B6) background. Since dendritic cells (DCs) are key cells of innate immunity, we determined whether G[alpha]i2-/- DCs have functional defects, influenced by strain background, that predispose to IBD.Methods: By breeding these strains to homozygosity for the first time, it became possible to study innate immunity in this animal model with more precision than ever before. Immature DCs were generated using bone marrow monoblasts cultured in the presence of GM-CSF (BMDCs), DC subsets sorted and responses to TLR9 activation were assayed.Results: In contrast to G[alpha]i2-/- B6, G[alpha]i2-/- 129 mice display accelerated onset and increased severity of colitis, abnormal mucosal DC distribution, accompanied by preponderance for Th1 and Th17-associated gut cytokine expression. TLR9 activation of BMDCs induces sustained p38 MAPK activation and greater Th1- and Th17-type cytokine secretion in both strains of G[alpha]i2-deficient compared to wildtype BMDCs. However, only B6 G[alpha]i2-/- BMDCs concomitantly produces IL-10 while G[alpha]i2-/- 129 BMDCs do not.Conclusions: Loss of G[alpha]i2 promotes a Th1/Th17 phenotype and relative IL-10 insufficiency in G[alpha]i2-/- 129 BMDCs may account for the striking difference in disease.(Inflamm Bowel Dis 2008)
Mucocutaneous manifestations in inflammatory bowel disease
[Idot]lhami Yüksel, Ömer Ba[scedil]ar, Hilmi Ataseven, [Idot]brahim Ertu[gbreve]rul, Mehmet Arhan, Mehmet [Idot]bi[scedil], Ülkü Da[gbreve]l[inodot], Bilge Tunç Demirel, Aysel Ülker, Sema Seçilmi[scedil], Nurgül [Scedil]a[scedil]maz Thu, 20 Nov 2008 15:40:00 -0000
Background: The aim of this study was to evaluate the prevalence and features of the major cutaneous manifestations (erythema nodosum [EN] and pyoderma gangrenosum [PG]) and to determine the associations between cutaneous manifestations and other extraintestinal manifestations in patients with inflammatory bowel disease (IBD).Methods: The mucocutaneous manifestations of patients with IBD were studied between December 2002 and June 2007. All patients underwent a detailed whole body examination by a gastroenterologist and dermatologist.Results: In all, 352 patients were included in this study; 34 patients (9.3%) presented with at least 1 major cutaneous manifestation. The prevalence of EN (26 patients) and PG (8 patients) in IBD was 7.4% and 2.3%, respectively. EN was more common in Crohn's disease (16/118) than ulcerative colitis (10/234) (P = 0.002). EN was found to be related to disease activity of the bowel (P = 0.026). The prevalence of arthritis was significantly higher in the IBD patients with EN (11/26) than in IBD patients without EN (53/326) (P = 0.006). Arthritis was more common in IBD patients with PG (7/8) than in IBD patients without PG (57/344) (P = 0.00). IBD patients with PG were significantly more likely to have uveitis (1/8) compared with IBD patients without PG (5/344) (P = 0.017).Conclusions: We found the prevalence of 2 important cutaneous manifestations to be 9.3% in IBD in Turkish patients. EN was found to be more common in Crohn's disease and is associated with an active episode of bowel disease and peripheral arthritis. In addition, PG was connected with uveitis and peripheral arthritis.(Inflamm Bowel Dis 2009)
Validation of interactive voice response system administration of the short inflammatory bowel disease questionnaire
Manuel Y. Lam, Hang Lee, Renee Bright, Joshua R. Korzenik, Bruce E. Sands Thu, 20 Nov 2008 15:40:00 -0000
Background: The Short Inflammatory Bowel Disease Questionnaire (SIBDQ) is a written, self-administered instrument measuring quality of life in IBD. We assessed the validity of an interactive voice response system (IVRS) as a new mode of administering the SIBDQ.Methods: An IVRS was designed using prerecorded questions to collect data via touchtone telephone. Subjects with Crohn's disease (CD) or ulcerative colitis (UC) were randomized into 2 groups with different orders of administration: written, self-administered followed by IVRS (S-I) or IVRS followed by written, self-administered (I-S). Half of the S-I group was also randomized to receive a second IVRS. Sixty-four subjects were studied: 30 in S-I, 34 in I-S.Results: The mean SIBDQ scores were not different between written and IVRS modes (P = 0.26) with r = 0.93. IVRS scores were lower in active than inactive CD (36.1 ± 9.6 versus 54.7 ± 8.6, P < 0.001) and lower in active than inactive UC (40.8 ± 9.6 versus 59.8 ± 10.0, P < 0.001). Mean scores correlated highly with disease activity indices, and were not different between first and second IVRS administrations (P = 0.85) with r = 0.92. IVRS had excellent internal consistency (Cronbach alpha = 0.90).Conclusions: IVRS administration of the SIBDQ yields results similar to written self-administration, with excellent procedural validity, test-retest reliability, and internal consistency.(Inflamm Bowel Dis 2009)

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